Impact of target volume delineation accuracy on locoregional control and survival after postoperative radiotherapy for colorectal cancer

doi:10.4240/wjgs.117559

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Aug 27, 2026; 18(8): 117559
Published online Aug 27, 2026. doi: 10.4240/wjgs.117559

Table 4 Univariate analysis of factors affecting disease-free survival

Factor	HR	95%CI	P value
Gender (male vs female)	1.153	0.682-1.950	0.596
Age (> 60 years vs ≤ 60 years)	1.284	0.768-2.146	0.339
ECOG score (2 vs 0-1)	1.562	0.785-3.107	0.204
Tumor location (colon vs rectum)	0.894	0.524-1.524	0.681
Differentiation (poor vs moderate-well)	1.418	0.757-2.656	0.275
pT stage (T4 vs T3)^a	1.856	1.126-3.059	0.015^a
pN stage (N2 vs N0-1)^a	1.924	1.187-3.118	0.008^a
Lymph node metastasis (N+ vs N0)^a	1.832	1.145-2.930	0.012^a
Vascular invasion (yes vs no)	1.473	0.886-2.449	0.136
Neural invasion (yes vs no)^a	1.726	1.041-2.863	0.034^a
Margin status (positive vs negative)^a	2.168	1.243-3.781	0.006^a
Preoperative CEA (elevated vs normal)^a	1.628	1.021-2.596	0.041^a
Preoperative CA19-9 (elevated vs normal)	1.384	0.824-2.323	0.218
Surgical approach (laparoscopic vs open)	0.823	0.495-1.368	0.452
Neoadjuvant therapy (yes vs no)	0.765	0.413-1.418	0.398
Chemotherapy regimen (single vs combination)	1.245	0.735-2.109	0.415
Target delineation (inaccurate vs accurate)^a	2.254	1.356-3.746	0.002^a

^aP < 0.10, included in multivariate analysis.

HR: Hazard ratio; CI: Confidence interval; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; ECOG: Eastern Cooperative Oncology Group.

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Citation: Xing Y, Gu M. Impact of target volume delineation accuracy on locoregional control and survival after postoperative radiotherapy for colorectal cancer. World J Gastrointest Surg 2026; 18(8): 117559
URL: https://www.wjgnet.com/1948-9366/full/v18/i8/117559.htm
DOI: https://dx.doi.org/10.4240/wjgs.117559