Association of severe thrombocytopenia with prognosis following transjugular intrahepatic portosystemic shunt in cirrhotic patients with portal hypertension

Table 3 Uni- and multivariable Cox regression analyses of the post-matched cohort

Characteristics	HR	95%CI		P value
		Lower	Upper
Univariable Cox regression
Age	1.048	1.020	1.076	< 0.001
Gender	1.262	0.658	2.422	0.483
Severe TCP	1.210	0.686	2.133	0.510
TIPS indications	1.182	0.626	2.230	0.607
WBC	1.047	0.953	1.150	0.340
RBC	0.713	0.447	1.137	0.155
Hb	1.004	0.992	1.016	0.550
PLT	1.002	0.996	1.008	0.505
ALT	1.004	1.0003	1.007	0.031
TBIL	1.016	1.009	1.022	< 0.001
Albumin	0.907	0.854	0.964	0.002
PT	1.036	0.983	1.093	0.189
INR	3.036	1.040	8.859	0.042
Creatinine	1.009	1.002	1.017	0.012
MELD-Na score	1.009	0.971	1.048	0.649
MELD score	1.096	1.019	1.180	0.014
Child-Pugh score	1.356	1.149	1.601	< 0.001
PALBI	2.348	1.336	4.124	0.003
ALBI	3.956	2.029	7.713	< 0.001
Model 1 multivariable cox regression
Age	1.041	1.014	1.068	0.003
Creatinine	1.011	1.004	1.018	0.002
Child-Pugh score	1.287	1.076	1.538	0.006
Model 2 multivariable cox regression
Age	1.043	1.016	1.070	0.002
MELD score	1.113	1.034	1.199	0.004
Model 3 multivariable cox regression
Age	1.041	1.013	1.069	0.003
Creatinine	1.012	1.005	1.018	0.001
PALBI	2.164	1.169	4.008	0.014
Model 4 multivariable cox regression
Age	1.039	1.012	1.066	0.004
Creatinine	1.012	1.005	1.018	< 0.001
ALBI	3.886	1.903	7.936	< 0.001

HR: Hazard ratio; CI: Confidence interval; TCP: Thrombocytopenia; TIPS: Transjugular intrahepatic portosystemic shunt; WBC: White blood cell count; RBC: Red blood cell count; Hb: Hemoglobin; PLT: Platelet count; ALT: Alanine aminotransferase; TBIL: Total bilirubin; PT: Prothrombin time; INR: International normalized ratio; MELD: Model for end-stage liver disease score; MELD-Na: Model for end-stage liver disease sodium score; PALBI: Platelet-albumin-bilirubin index; ALBI: Albumin-bilirubin index.