Association of severe thrombocytopenia with prognosis following transjugular intrahepatic portosystemic shunt in cirrhotic patients with portal hypertension

doi:10.4240/wjgs.v18.i7.120610

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Jul 27, 2026; 18(7): 120610
Published online Jul 27, 2026. doi: 10.4240/wjgs.v18.i7.120610

Table 2 Uni- and multivariable Cox regression analyses of the pre-matched cohort

Characteristics	HR	95%CI		P value
Characteristics	HR	Lower	Upper	P value
Univariable Cox regression
Age	1.038	1.018	1.058	< 0.001
Gender	1.084	0.674	1.742	0.740
Severe TCP	1.695	1.078	2.665	0.022
TIPS indications	0.533	0.341	0.834	0.006
WBC	0.962	0.886	1.044	0.355
RBC	0.664	0.500	0.881	0.005
Hb	0.998	0.991	1.006	0.618
PLT	0.997	0.992	1.001	0.165
ALT	0.999	0.996	1.003	0.764
TBIL	1.010	1.004	1.016	< 0.001
Albumin	0.902	0.860	0.946	< 0.001
PT	1.019	0.986	1.053	0.268
INR	1.839	1.049	3.226	0.033
Creatinine	1.006	1.004	1.008	< 0.001
MELD-Na score	1.006	0.996	1.016	0.233
MELD score	1.078	1.029	1.128	0.001
Child-Pugh score	1.284	1.136	1.451	< 0.001
PALBI	2.511	1.668	3.780	< 0.001
ALBI	3.007	1.875	4.820	< 0.001
Model 1 multivariable cox regression
Age	1.046	1.025	1.068	< 0.001
Severe TCP	1.974	1.224	3.184	0.005
Creatinine	1.006	1.004	1.009	< 0.001
Child-Pugh score	1.268	1.109	1.451	< 0.001
Model 2 multivariable cox regression
Age	1.047	1.025	1.068	< 0.001
Severe TCP	1.687	1.054	2.701	0.029
MELD score	1.077	1.025	1.131	0.003
Model 3 multivariable cox regression
Age	1.040	1.020	1.061	< 0.001
Creatinine	1.007	1.004	1.009	< 0.001
PALBI score	2.414	1.566	3.723	< 0.001
Model 4 multivariable cox regression
Age	1.039	1.018	1.060	< 0.001
Severe TCP	2.066	1.298	3.287	0.002
Creatinine	1.007	1.004	1.009	< 0.001
ALBI	2.783	1.689	4.584	< 0.001

HR: Hazard ratio; CI: Confidence interval; TCP: Thrombocytopenia; TIPS: Transjugular intrahepatic portosystemic shunt; WBC: White blood cell count; RBC: Red blood cell count; Hb: Hemoglobin; PLT: Platelet count; ALT: Alanine aminotransferase; TBIL: Total bilirubin; PT: Prothrombin time; INR: International normalized ratio; MELD: Model for end-stage liver disease score; MELD-Na: Model for end-stage liver disease sodium score; PALBI: Platelet-albumin-bilirubin index; ALBI: Albumin-bilirubin index.

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Citation: Zhang L, Xu SQ, Zhu YJ, Dong L, Yin L, Xiao JC, Cheng DL, Wang RF, Zhou CZ. Association of severe thrombocytopenia with prognosis following transjugular intrahepatic portosystemic shunt in cirrhotic patients with portal hypertension. World J Gastrointest Surg 2026; 18(7): 120610
URL: https://www.wjgnet.com/1948-9366/full/v18/i7/120610.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i7.120610

Zhang L, Xu SQ, Zhu YJ, Dong L, Yin L, Xiao JC, Cheng DL, Wang RF, Zhou CZ. Association of severe thrombocytopenia with prognosis following transjugular intrahepatic portosystemic shunt in cirrhotic patients with portal hypertension. World J Gastrointest Surg 2026; 18(7): 120610 [DOI: 10.4240/wjgs.v18.i7.120610]

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