Association of severe thrombocytopenia with prognosis following transjugular intrahepatic portosystemic shunt in cirrhotic patients with portal hypertension

Table 1 The baseline characteristics, mean ± SD/n (%)/median (interquartile range)

Characteristics	Pre-match			Post-match
	Severe TCP (n = 131)	Non-severe TCP (n = 303)	P value	Severe TCP (n = 90)	Non-severe TCP (n = 90)	P value
Age	53.1 ± 10.4	55.3 ± 12.0	0.069	53.8 ± 10.9	54.1 ± 11.4	0.852
Gender			0.111			0.506
Male	95 (72.5)	196 (64.7)		67 (74.4)	63 (70.0)
Female	36 (27.5)	107 (35.3)		23 (25.6)	27 (30.0)
Etiology of cirrhosis			0.747			0.812
HBV	91 (69.5)	198 (65.3)		68 (75.6)	69 (76.7)
HCV	16 (12.2)	32 (10.6)		6 (6.7)	4 (4.4)
ALD	6 (4.6)	21 (6.9)		3 (3.3)	5 (5.6)
AIH	4 (3.0)	12 (4.0)		3 (3.3)	3 (3.3)
Others	14 (10.7)	40 (13.2)		10 (11.1)	9 (10.0)
TIPS indications			0.484			0.747
Gastrointestinal bleeding	89 (67.9)	216 (71.3)		61 (67.8)	63 (70.0)
Recurrent/refractory ascites	42 (32.1)	87 (28.7)		29 (32.2)	27 (30.0)
Child-Pugh score	7.0 (7.0, 9.0)	7.0 (6.0, 8.0)	0.008	7.0 (6.8, 8.3)	8.0 (7.0, 8.8)	0.562
MELD score	10.6 ± 4.5	8.5 ± 5.0	< 0.001	10.1 ± 4.2	8.5 ± 4.6	0.016
MELD-Na score	9.9 (7.6, 13.3)	8.3 (5.6, 12.3)	< 0.001	9.8 (7.5, 13.6)	8.8 (5.0, 13.6)	0.067
PALBI	-1.8 ± 0.4	-2.5 ± 0.5	< 0.001	-1.9 ± 0.5	-2.4 ± 0.5	< 0.001
ALBI	-1.8 (-2.1, -1.5)	-2.0 (-2.3, -1.6)	0.009	-1.8 (-2.1, -1.5)	-1.9 (-2.2, -1.6)	0.970
Ammonia (μmol/L)	32.6 (19.1, 45.6)	34.4 (19.8, 67.7)	0.363	33.2 (22.9, 45.2)	42.5 (20.3, 69.7)	0.507
Albumin (g/L)	32.6 ± 5.4	33.6 ± 5.3	0.094	33.5 ± 5.6	32.3 ± 5.2	0.148
Hb (g/L)	72.0 (64.0, 87.0)	84.0 (66.0, 109.8)	< 0.001	76 (68.8, 88.0)	69.5 (60.3, 80.3)	0.408
PT (second)	15.8 (13.8, 17.7)	14.3 (12.7, 15.9)	< 0.001	15.8 (14.4, 17.5)	14.3 (12.9, 16.0)	0.001
APTT (second)	39.5 (31.7, 44.3)	34.0 (28.8, 40.6)	< 0.001	37.2 (31.3, 43.3)	33.4 (28.9, 40.5)	0.026
TT (second)	17.6 ± 2.8	18.11 ± 6.8	0.371	17.3 ± 2.7	18.8 ± 9.6	0.143
INR	1.3 (1.2, 1.5)	1.2 (1.0, 1.4)	< 0.001	1.4 (1.2, 1.5)	1.2 (1.1, 1.3)	< 0.001
ALT (U/L)	24.1 (18.0, 34.0)	21.0 (15.0, 33.0)	0.647	24.6 (19.8, 32.9)	20.0 (15.0, 33.5)	0.027
TBIL (μmol/L)	21.9 (15.0, 27.5)	18.8 (13.7, 33.0)	0.063	21.0 (13.8, 30.4)	15.6 (11.2, 24.2)	0.084
Creatinine	58.0 (49.0, 70.0)	65.5 (55.3, 81.0)	0.333	60.6 (51.0, 81.3)	62.0 (51.8, 75.8)	0.817
PLT (× 109/L)	39.0 (33.0, 44.0)	83.0 (61.3, 119.5)	< 0.001	39.1 (31.8, 44.3)	76.0 (62.0, 101.0)	< 0.001
WBC (× 109/L)	2.6 (2.0, 3.7)	4.0 (2.5, 5.8)	< 0.001	2.8 (2.0, 4.3)	3.5 (2.3, 4.8)	0.249
RBC (× 109/L)	2.6 (2.2, 3.0)	3.1 (2.5, 3.9)	< 0.001	2.7 (2.3, 3.2)	2.8 (2.5, 3.3)	0.062
PPG (mmHg)
Before TIPS	26.9 ± 5.9	26.4 ± 5.1	0.577	26.7 ± 5.7	26.9 ± 5.2	0.799
After TIPS	12.8 ± 3.4	11.9 ± 3.4	0.061	12.2 ± 3.7	13.1 ± 3.0	0.215

TCP: Thrombocytopenia; HBV: Hepatitis B virus; HCV: Hepatitis C virus; ALD: Alcoholic liver disease; AIH: Autoimmune hepatitis; TIPS: Transjugular intrahepatic portosystemic shunt; MELD: Model for end-stage liver disease score; MELD-Na: Model for end-stage liver disease sodium score; PALBI: Platelet-albumin-bilirubin index; ALBI: Albumin-bilirubin index; Hb: Hemoglobin; PT: Prothrombin time; APTT: Activated partial thromboplastin time; TT: Thrombin time; INR: International normalized ratio; ALT: Alanine aminotransferase; TBIL: Total bilirubin; PLT: Platelet count; WBC: White blood cell count; RBC: Red blood cell count; PPG: Portosystemic pressure gradient.