Anti-reflux mucosectomy is associated with better short-term symptoms than double-dose proton pump inhibitor in reflux esophagitis patients

doi:10.4240/wjgs.119941

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World Journal of Gastrointestinal Surgery

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1948-9366

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Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Jun 27, 2026; 18(6): 119941
Published online Jun 27, 2026. doi: 10.4240/wjgs.119941

Table 4 Patient pre- and post-operative symptoms outcomes between the two groups, mean ± SD

	ARMS (n = 14)	Double-dose PPI (n = 14)	P value
Preoperative
RSI	29.36 ± 4.80	28.43 ± 6.38	0.667
GERD-HRQL	39.93 ± 3.69	41.57 ± 4.26	0.285
GERDQ	14.21 ± 2.67	13.71 ± 2.55	0.617
RDQ	30.36 ± 5.36	31.71 ± 4.50	0.474
LA grade (C-D)	9	9	1.000
3 weeks postoperative
RSI	17.93 ± 6.94	24.29 ± 4.12	0.007
GERD-HRQL	27.71 ± 7.65	35.21 ± 4.56	0.004
GERDQ	7.64 ± 2.41	11.64 ± 2.92	0.001
RDQ	18.14 ± 7.04	27.07 ± 4.51	< 0.001
3 months postoperative
RSI	16.57 ± 2.47	22.64 ± 2.9	< 0.001
GERD-HRQL	27.57 ± 4.72	38.35 ± 8.02	< 0.001
GERDQ	7.86 ± 2.25	10.57 ± 2.5	0.006
RDQ	18.00 ± 6.97	27.79 ± 3.08	< 0.001
LA grade (C-D)	2	6	0.209¹

¹Comparison was conducted with Fisher’s exact test.

PPI: Proton pump inhibitor; ARMS: Anti-reflux mucosectomy; RSI: Reflux symptom index; GERDQ: Gastroesophageal reflux disease questionnaire; GERD-HRQL: Gastroesophageal reflux disease-health-related quality of life; RDQ: Reflux disease questionnaire.

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Citation: Jiang WJ, Liu J, Liu YL, Tang MD, Sheng Y, Wang YT. Anti-reflux mucosectomy is associated with better short-term symptoms than double-dose proton pump inhibitor in reflux esophagitis patients. World J Gastrointest Surg 2026; 18(6): 119941
URL: https://www.wjgnet.com/1948-9366/full/v18/i6/119941.htm
DOI: https://dx.doi.org/10.4240/wjgs.119941

Jiang WJ, Liu J, Liu YL, Tang MD, Sheng Y, Wang YT. Anti-reflux mucosectomy is associated with better short-term symptoms than double-dose proton pump inhibitor in reflux esophagitis patients. World J Gastrointest Surg 2026; 18(6): 119941 [DOI: 10.4240/wjgs.119941]

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