Anti-reflux mucosectomy is associated with better short-term symptoms than double-dose proton pump inhibitor in reflux esophagitis patients

doi:10.4240/wjgs.119941

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World Journal of Gastrointestinal Surgery

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1948-9366

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Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Jun 27, 2026; 18(6): 119941
Published online Jun 27, 2026. doi: 10.4240/wjgs.119941

Table 1 Patient demographics and characteristics between the two groups, mean ± SD/n (%)

Characteristic	ARMS (n = 14)	Double-dose PPI (n = 14)	P value
Male	5 (35.7)	5 (35.7)	1.000
Age, year	57.93 ± 12.33	53.79 ± 12.75	0.390
BMI, kg/m²	22.79 ± 1.43	22.56 ± 1.72	0.697
Smoker
Never	10 (71.4)	8 (57.1)	0.430
Former	1 (7.1)	1 (7.1)
Current	3 (21.4)	5 (35.7)
Hypertension	3 (21.4)	4 (28.6)	1.000¹
Asthma	0 (0)	1 (7.1)	1.000¹
Diabetes	2 (14.3)	2 (14.3)	1.000¹
Preop PPI use	14 (100.0)	14 (100.0)	1.000¹
Preop pH study	14 (100.0)	14 (100.0)	1.000¹
AET	9.09 ± 1.44	8.33 ± 1.65	0.204
Esophagitis	14 (100.0)	14 (100.0)	1.000¹
Follow-up, months	6.93 ± 2.50	7.43 ± 2.10	0.571

¹Comparison was conducted with Fisher’s exact test.

PPI: Proton pump inhibitor; ARMS: Anti-reflux mucosectomy; BMI: Body mass index; AET: Acid exposure time; pH: Potential of hydrogen.

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Citation: Jiang WJ, Liu J, Liu YL, Tang MD, Sheng Y, Wang YT. Anti-reflux mucosectomy is associated with better short-term symptoms than double-dose proton pump inhibitor in reflux esophagitis patients. World J Gastrointest Surg 2026; 18(6): 119941
URL: https://www.wjgnet.com/1948-9366/full/v18/i6/119941.htm
DOI: https://dx.doi.org/10.4240/wjgs.119941

Jiang WJ, Liu J, Liu YL, Tang MD, Sheng Y, Wang YT. Anti-reflux mucosectomy is associated with better short-term symptoms than double-dose proton pump inhibitor in reflux esophagitis patients. World J Gastrointest Surg 2026; 18(6): 119941 [DOI: 10.4240/wjgs.119941]

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