Efficacy of linaclotide with polyethylene glycol at high risk of inadequate bowel preparation: A randomized controlled trial

doi:10.4240/wjgs.119538

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Jun 27, 2026; 18(6): 119538
Published online Jun 27, 2026. doi: 10.4240/wjgs.119538

Table 2 Comparison of the Boston score between the two groups, mean ± SD

Segment	3 L PEG (n = 81)	Linaclotide + 3 L PEG (n = 80)	Difference between groups (95%CI)	P value
Right colon	1.642 ± 0.577	1.938 ± 0.512	0.296 (0.126-0.465)	< 0.001
Transverse colon	1.938 ± 0.659	2.350 ± 0.618	0.412 (0.213-0.611)	< 0.001
Left colon	2.012 ± 0.581	2.513 ± 0.595	0.500 (0.317-0.683)	< 0.001
Total BBPS	5.593 ± 1.579	6.800 ± 1.444	1.207 (0.736-1.679)	< 0.001
Adequate prep (%)	58.025	86.250	28.230 (15.100-42.840)	< 0.001

BBPS: Boston bowel preparation scale; CI: Confidence interval; PEG: Polyethylene glycol.

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Citation: Li WM, Wang XP, Li YX, Wang YD, Sun YJ, Li GD, Wu JQ. Efficacy of linaclotide with polyethylene glycol at high risk of inadequate bowel preparation: A randomized controlled trial. World J Gastrointest Surg 2026; 18(6): 119538
URL: https://www.wjgnet.com/1948-9366/full/v18/i6/119538.htm
DOI: https://dx.doi.org/10.4240/wjgs.119538

Li WM, Wang XP, Li YX, Wang YD, Sun YJ, Li GD, Wu JQ. Efficacy of linaclotide with polyethylene glycol at high risk of inadequate bowel preparation: A randomized controlled trial. World J Gastrointest Surg 2026; 18(6): 119538 [DOI: 10.4240/wjgs.119538]

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