Combined inflammatory markers and amylase levels for early detection of postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy

doi:10.4240/wjgs.115706

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Jun 27, 2026; 18(6): 115706
Published online Jun 27, 2026. doi: 10.4240/wjgs.115706

Table 4 Pairwise receiver operating characteristic curve comparison of biomarkers for clinically relevant postoperative pancreatic fistula detection

Pairwise comparison of receiver operating characteristic curves		POD1	POD3
CRP vs DAC	Difference between areas	0.208	0.142
CRP vs DAC	P value	0.017	0.118
CRP vs DSACR	Difference between areas	0.004	0.075
CRP vs DSACR	P value	0.961	0.342
CRP vs IL-6	Difference between areas	0.154	0.103
CRP vs IL-6	P value	0.086	0.100
CRP vs IL-8	Difference between areas	0.050	0.085
CRP vs IL-8	P value	0.627	0.173
CRP vs SAC	Difference between areas	0.017	0.244
CRP vs SAC	P value	0.864	0.008
DAC vs DSACR	Difference between areas	0.203	0.217
DAC vs DSACR	P value	0.007	0.009
DAC vs IL-6	Difference between areas	0.054	0.245
DAC vs IL-6	P value	0.441	0.005
DAC vs IL-8	Difference between areas	0.158	0.227
DAC vs IL-8	P value	0.079	0.006
DAC vs SAC	Difference between areas	0.225	0.102
DAC vs SAC	P value	0.001	0.443
DSACR vs IL-6	Difference between areas	0.150	0.028
DSACR vs IL-6	P value	0.123	0.671
DSACR vs IL-8	Difference between areas	0.046	0.010
DSACR vs IL-8	P value	0.662	0.881
DSACR vs SAC	Difference between areas	0.022	0.319
DSACR vs SAC	P value	0.8625	< 0.001
IL-6 vs IL-8	Difference between areas	0.104	0.018
IL-6 vs IL-8	P value	0.239	0.744
IL-6 vs SAC	Difference between areas	0.171	0.347
IL-6 vs SAC	P value	0.025	< 0.001
IL-8 vs SAC	Difference between areas	0.067	0.329
IL-8 vs SAC	P value	0.477	< 0.001

CRP: C-reactive protein; DAC: Drain fluid amylase concentration; DSACR: Drain-to-serum amylase concentration ratio; IL: Interleukin; POD: Postoperative day; SAC: Serum amylase concentration.

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Citation: Yang JK, Gu YQ, He ZG, Liu FB. Combined inflammatory markers and amylase levels for early detection of postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy. World J Gastrointest Surg 2026; 18(6): 115706
URL: https://www.wjgnet.com/1948-9366/full/v18/i6/115706.htm
DOI: https://dx.doi.org/10.4240/wjgs.115706

Yang JK, Gu YQ, He ZG, Liu FB. Combined inflammatory markers and amylase levels for early detection of postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy. World J Gastrointest Surg 2026; 18(6): 115706 [DOI: 10.4240/wjgs.115706]

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