Combined inflammatory markers and amylase levels for early detection of postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy

doi:10.4240/wjgs.115706

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Jun 27, 2026; 18(6): 115706
Published online Jun 27, 2026. doi: 10.4240/wjgs.115706

Table 3 Diagnostic accuracy of biomarkers for clinically relevant postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy on postoperative day 3

ROC curve analysis	Serum amylase concentration (U/L)	Drain fluid amylase concentration (U/L)	Drain-to-serum amylase concentration ratio	C-reactive protein (pg/mL)	IL-8 (pg/mL)	IL-6 (pg/mL)
Areas under the ROC curve	0.648	0.546	0.865	0.790	0.875	0.893
95%CI	0.522-0.761	0.420-0.668	0.760-0.936	0.674-0.880	0.772-0.943	0.794-0.956
P value	0.043	0.525	< 0.001	< 0.001	< 0.001	< 0.001
Youden index J	0.5466	0.2688	0.8011	0.515	0.635	0.668
Associated criterion	> 734	≤ 168.36	> 14	> 336.19	> 78.23	> 177.9
Sensitivity	93.55	93.55	96.77	70.97	77.42	80.65
Specificity	61.11	33.33	83.33	80.56	86.11	86.11

IL: Interleukin; ROC: Receiver operating characteristic.

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Citation: Yang JK, Gu YQ, He ZG, Liu FB. Combined inflammatory markers and amylase levels for early detection of postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy. World J Gastrointest Surg 2026; 18(6): 115706
URL: https://www.wjgnet.com/1948-9366/full/v18/i6/115706.htm
DOI: https://dx.doi.org/10.4240/wjgs.115706

Yang JK, Gu YQ, He ZG, Liu FB. Combined inflammatory markers and amylase levels for early detection of postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy. World J Gastrointest Surg 2026; 18(6): 115706 [DOI: 10.4240/wjgs.115706]

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