Combined inflammatory markers and amylase levels for early detection of postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy

Table 2 Diagnostic accuracy of biomarkers for clinically relevant postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy on postoperative day 1

ROC curve analysis	Drain fluid amylase concentration (U/L)	Serum amylase concentration (U/L)	Drain-to-serum amylase concentration ratio	C-reactive protein (pg/mL)	IL-8 (pg/mL)	IL-6 (pg/mL)
Areas under the ROC curve	0.866	0.641	0.662	0.658	0.708	0.812
95%CI	0.760-0.937	0.514-0.754	0.536-0.773	0.532-0.769	0.584-0.813	0.698-0.897
P value	< 0.001	0.041	0.017	0.019	0.003	< 0.001
Youden index J	0.672	0.302	0.3486	0.308	0.543	0.534
Associated criterion	> 3767	> 82.68	> 24.9	> 135.1	> 88.09	> 244.91
Sensitivity	83.87	77.42	70.97	41.94	70.97	64.52
Specificity	83.33	52.78	63.89	88.89	83.33	88.89

IL: Interleukin; ROC: Receiver operating characteristic.