Evolution of early fluid therapy in acute pancreatitis: Balancing perfusion needs with fluid toxicity

doi:10.4240/wjgs.115426

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Jun 27, 2026; 18(6): 115426
Published online Jun 27, 2026. doi: 10.4240/wjgs.115426

Table 3 Representative studies comparing Lactated Ringer’s solution with normal saline in acute pancreatitis

Ref.	Year	Study type/population	Main findings	Comment
Lee et al[23]	2021	Randomized trial; mild AP	LR favored	Key trial
Zhou et al[56]	2021	Meta-analysis of RCTs	Pooled signal favored LR	Synthesis
Kow et al[25]	2022	Systematic review and meta-analysis	LR remained favorable	Consistent
Vedantam et al[28]	2022	Updated meta-analysis	Benefit varied by endpoint	Mixed
Hong et al[29]	2024	Updated meta-analysis	Recent pooled data favored LR	Supports LR
Guilabert et al[33]	2024	Multicenter RCT protocol	Prospective testing ongoing	Ongoing

AP: Acute pancreatitis; LR: Lactated Ringer’s solution; RCT: Randomized controlled trial.

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Citation: Li XM, Tao YR, Chen JQ, Chen Y. Evolution of early fluid therapy in acute pancreatitis: Balancing perfusion needs with fluid toxicity. World J Gastrointest Surg 2026; 18(6): 115426
URL: https://www.wjgnet.com/1948-9366/full/v18/i6/115426.htm
DOI: https://dx.doi.org/10.4240/wjgs.115426

Li XM, Tao YR, Chen JQ, Chen Y. Evolution of early fluid therapy in acute pancreatitis: Balancing perfusion needs with fluid toxicity. World J Gastrointest Surg 2026; 18(6): 115426 [DOI: 10.4240/wjgs.115426]

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