Dynamic monitoring of serum tumor markers in predicting recurrence after radical gastrectomy for gastric cancer

doi:10.4240/wjgs.v18.i5.116869

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. May 27, 2026; 18(5): 116869
Published online May 27, 2026. doi: 10.4240/wjgs.v18.i5.116869

Table 8 Median disease-free survival of patients with different dynamic change patterns of tumor markers

Marker	Dynamic change pattern	Number of cases	Median DFS (months)	χ²	P value
CEA	Persistently normal	95	Not reached [median follow-up 36.5 months, 36-month survival rate 926% (85.3-96.5%)]	86.524	< 0.001
	Postoperative normalization	70	42.0 (35.0, 48.0)
	Persistently elevated	10	15.5 (12.0, 19.0)
	Recurrent elevation	22	18.0 (15.0, 22.0)
	Progressive elevation	14	12.0 (9.0, 16.0)
	Delayed elevation	2	20.0 (16.0, 25.0)
	Subtotal	213
CA19-9	Persistently normal	104	Not reached [median follow-up 36.5 months, 36-month survival rate 933% (86.8-96.8%)]	78.326	< 0.001
	Postoperative normalization	64	40.0 (34.0, 46.0)
	Persistently elevated	7	14.0 (11.0, 18.0)
	Recurrent elevation	22	17.0 (14.0, 21.0)
	Progressive elevation	19	11.0 (8.0, 15.0)
	Delayed elevation	3	19.0 (15.0, 24.0)
	Subtotal	213
CA72-4	Persistently normal	111	Not reached [median follow-up 36.5 months, 36-month survival rate 946% (88.5-97.6%)]	74.185	< 0.001
	Postoperative normalization	63	39.0 (33.0, 45.0)
	Persistently elevated	7	13.5 (10.0, 17.0)
	Recurrent elevation	19	16.0 (13.0, 20.0)
	Progressive elevation	18	10.0 (7.0, 14.0)
	Delayed elevation	6	18.0 (14.0, 23.0)
	Subtotal	213
CA125	Persistently normal	116	Not reached [median follow-up 36.5 months, 36-month survival rate 957% (90.2-98.2%)]	70.847	< 0.001
	Postoperative normalization	58	38.0 (32.0, 44.0)
	Persistently elevated	8	12.5 (9.0, 16.0)
	Recurrent elevation	19	15.0 (12.0, 19.0)
	Progressive elevation	17	9.0 (7.0, 13.0)
	Delayed elevation	5	17.0 (13.0, 22.0)
	Subtotal	213

Median disease-free survival is expressed as median (quartiles) [M (Q1, Q3)]. DFS: Disease-free survival; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; CA72-4: Carbohydrate antigen 72-4; CA125: Carbohydrate antigen 125.

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Citation: Zhang WH, Wu M, Zhong CY. Dynamic monitoring of serum tumor markers in predicting recurrence after radical gastrectomy for gastric cancer. World J Gastrointest Surg 2026; 18(5): 116869
URL: https://www.wjgnet.com/1948-9366/full/v18/i5/116869.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i5.116869

Zhang WH, Wu M, Zhong CY. Dynamic monitoring of serum tumor markers in predicting recurrence after radical gastrectomy for gastric cancer. World J Gastrointest Surg 2026; 18(5): 116869 [DOI: 10.4240/wjgs.v18.i5.116869]

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