Dynamic monitoring of serum tumor markers in predicting recurrence after radical gastrectomy for gastric cancer

Table 5 Predictive value of preoperative tumor markers for recurrence

Marker	Cutoff value	AUC	95%CI	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	vs four combined P value	Significance after correction
CEA	6.2 ng/mL	0.742	0.673-0.811	67.6	72.4	53.6	82.5	0.032	NS (α = 0.0125)
CA19-9	38.5 U/mL	0.718	0.646-0.790	64.7	70.3	50.8	80.7	0.015	NS (α = 0.0125)
CA72-4	8.5 U/mL	0.756	0.688-0.824	70.6	75.2	56.9	84.2	0.041	NS (α = 0.0125)
CA125	32.5 U/mL	0.738	0.668-0.808	66.2	73.1	52.7	82.8	0.028	NS (α = 0.0125)
Four combined	-	0.825	0.765-0.885	80.9	76.6	62.8	89.2	Reference	Reference

Bonferroni method was used to correct for multiple comparisons, with corrected significance level α = 0.0125 (0.05/4). AUC: Area under the curve; CI: Confidence interval; NS: Not significant; PPV: Positive predictive value; NPV: Negative predictive value; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; CA72-4: Carbohydrate antigen 72-4; CA125: Carbohydrate antigen 125.