Establishment and validation of an intratumoral fibrosis-based nomogram for predicting aggressive recurrence after liver resection in hepatocellular carcinoma

Table 4 Univariable and multivariable Fine-Gray analysis in training cohort

Characteristics	Univariable Fine-Gray analysis			Multivariable Fine-Gray analysis
	β value	SHR 95%CI	P value	β value	SHR 95%CI	P value
Age (years)	-0.008	0.992 (0.980, 1.000)	0.210	-	-	-
Tumor size (mm)	0.015	1.020 (1.010, 1.020)	< 0.001	0.012	1.010 (1.010, 1.020)	< 0.001
Neutrophil (× 109)	0.162	1.180 (1.090, 1.260)	< 0.001	0.083	1.090 (1.000, 1.180)	0.046
Lymphocyte (× 109)	-0.125	0.882 (0.690, 1.130)	0.320	-	-	-
Platelet (× 109)	0.004	1.000 (1.000, 1.010)	< 0.001	-	-	-
Monocyte (× 109)	1.370	3.950 (2.300, 6.800)	< 0.001	-	-	-
Albumin (g/L)	-0.040	0.961 (0.927, 0.996)	0.028	-	-	-
Total bilirubin (µmol/L)	-0.016	0.985 (0.968, 1.000)	0.068	-	-	-
ALT (U/L)	-0.001	0.999 (0.995, 1.000)	0.480	-	-	-
AST (U/L)	0.002	1.000 (0.999, 1.000)	0.240	-	-	-
Creatine (µmol/L)	-0.002	1.000 (0.992, 1.010)	0.960	-	-	-
INR	1.250	3.500 (1.070, 11.400)	0.038	-	-	-
Intratumoral fibrosis
Low	Ref	-	-	-	-	-
High	1.650	5.230 (3.900, 7.010)	< 0.001	1.557	4.750 (3.530, 6.370)	< 0.001
MVI
Negative	Ref	-	-	-	-	-
Positive	1.450	4.280 (3.180, 5.760)	< 0.001	1.165	3.200 (2.360, 4.350)	< 0.001
Gender
Female	Ref	-	-	-	-	-
Male	0.198	1.220 (0.803, 1.850)	0.350	-	-	-
Liver cirrhosis
Absence	Ref	-	-	-	-	-
Presence	-0.050	0.951 (0.716, 1.260)	0.730	-	-	-
AFP (ng/mL)
≤ 200	Ref	-	-	-	-	-
> 200	0.481	1.620 (1.220, 2.150)	< 0.001	-	-	-
Tumor grade
Well/moderate	Ref	-	-	-	-	-
Poor	0.560	1.750 (1.320, 2.330)	< 0.001	-	-	-
Satellite lesion
Absence	Ref	-	-	-	-	-
Presence	0.821	2.270 (1.700, 3.040)	< 0.001	-	-	-
VETC pattern
Absence	Ref	-	-	-	-	-
Presence	0.453	1.570 (1.180, 2.100)	0.002	-	-	-
Underlying liver diseases
Absence	Ref	-	-	-	-	-
HBV	0.078	1.081 (0.679, 1.720)	0.740	-	-	-
Others	-0.234	0.791 (0.408, 1.540)	0.490	-	-	-

SHR: Subdistribution hazard ratio; CI: Confidence interval; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; INR: International normalized ratio; AFP: Alpha-fetoprotein; MVI: Microvascular invasion; VETC: Vessels that encapsulate tumor clusters; Ref: Reference.