Mucinous rectal adenocarcinoma and neoadjuvant therapy: Implications for surgical practice

doi:10.4240/wjgs.v18.i5.115825

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. May 27, 2026; 18(5): 115825
Published online May 27, 2026. doi: 10.4240/wjgs.v18.i5.115825

Table 2 Comparison of the four trials using total neoadjuvant therapy in the study arm

Study name	Primary endpoints	TNT arm	Control arm	pCR (%) study	pCR (%) control	DFS (months) study	DFS (months) control
PRODIGE23	3-year DFS	CTX/CRT/TME	CRT/TME	28	12	76	69
RAPIDO	3-year DRTF	SCRT/CTX/TME	CTX/CRT/TME	28	14	23.7	30.4
OPRA	DFS	CTX/CRT/TME	CRT/CTX/TME	NA	NA	76	76
STELLAR	DFS	SCRT/CTX/TME	CRT/TME	17.2	13.9	64.3	62.3

CRT: Long-course chemoradiotherapy; CTX: Chemotherapy; DFS: Disease-free survival; DRTF: Disease-related treatment failure; NA: Not available; pCR: Pathologic complete response; SCRT: Short-course radiotherapy; TME: Total mesorectal excision; TNT: Total neoadjuvant therapy.

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Citation: Patriti A, Graziano F, Chiari R. Mucinous rectal adenocarcinoma and neoadjuvant therapy: Implications for surgical practice. World J Gastrointest Surg 2026; 18(5): 115825
URL: https://www.wjgnet.com/1948-9366/full/v18/i5/115825.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i5.115825

Patriti A, Graziano F, Chiari R. Mucinous rectal adenocarcinoma and neoadjuvant therapy: Implications for surgical practice. World J Gastrointest Surg 2026; 18(5): 115825 [DOI: 10.4240/wjgs.v18.i5.115825]

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