Impact of oxiracetam on postoperative delirium in elderly patients undergoing laparoscopic gastrointestinal surgery

Table 3 Relationship between oxiracetam and inflammatory factor levels

Time	Characteristic	Control group	Oxiracetam group	P value
n		91	82
Pre	IL-1β	1.25 (0.80, 1.71)	1.27 (0.87, 1.89)	0.792
	IL-2	1.95 (1.45, 2.34)	2.12 (1.54, 2.81)	0.371
	IL-6	9.5 (7.9, 10.7)	9.4 (7.8, 10.6)	0.831
	IL-8	26 (21, 30)	25 (20, 31)	0.582
	IL-10	1.24 (0.89, 2.34)	1.30 (0.90, 2.30)	0.711
	TNF-α	2.28 (1.07, 2.84)	1.78 (1.25, 2.56)	0.408
Day 1	IL-1β	1.95 (1.39, 2.98)	1.63 (1.08, 3.10)	0.012
	IL-2	1.79 (1.65, 2.07)	1.92 (1.42, 3.50)	0.222
	IL-6	79 (58, 89)	36 (27, 55)	< 0.001
	IL-8	28 (22, 36)	15 (11, 24)	< 0.001
	IL-10	3.4 (2.2, 4.9)	3.8 (2.4, 6.4)	0.314
	TNF-α	2.01 (1.31, 2.86)	1.78 (1.24, 2.53)	0.218
Day 2	IL-1β	2.33 (1.79, 2.89)	1.92 (1.45, 2.77)	0.011
	IL-2	1.56 (1.18, 1.85)	2.34 (1.34, 3.47)	< 0.001
	IL-6	76 (60, 94)	39 (22, 77)	< 0.001
	IL-8	41 (32, 49)	27 (17, 46)	< 0.001
	IL-10	2.9 (2.0, 5.1)	4.5 (2.5, 6.0)	0.008
	TNF-α	2.45 (1.18, 2.99)	2.01 (1.70, 2.92)	0.892
Day 7	IL-1β	1.76 (1.09, 2.58)	1.25 (0.97, 1.58)	0.005
	IL-2	1.61 (1.39, 2.01)	2.14 (1.34, 3.48)	0.013
	IL-6	31 (16, 44)	12 (9, 22)	< 0.001
	IL-8	19 (15, 24)	16 (12, 26)	0.093
	IL-10	2.15 (1.65, 3.27)	3.57 (1.78, 4.27)	0.012
	TNF-α	2.25 (1.65, 2.78)	2.12 (1.54, 2.76)	0.705

TNF-α: Tumor necrosis factor-α; IL: Interleukin.