Repairing the impaired gut vascular barrier as a novel therapeutic target for prolonged postoperative ileus: A scoping review

doi:10.4240/wjgs.v18.i4.117318

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Apr 27, 2026; 18(4): 117318
Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.117318

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Figure 2 Anatomy of the gut vascular barrier. The gut vascular barrier is present underneath the intestinal epithelium. It is primarily composed of a monolayer of intestinal microvascular endothelial cells (IMVECs) and is supported by enteric glial cells and pericytes. IMVECs are connected through tight junction and adherens junction. Plasmalemma vesicle-associated protein-1 is a distinctive protein of IMVECs. Created in BioRender (Supplementary material).

Citation: Shen DL, Wan L, Zhang XC, Fang YD, Jiang HC, Wei YC, Chen LF, Wu ZM, Ye CC, Pei C, Zhou H, Qian L. Repairing the impaired gut vascular barrier as a novel therapeutic target for prolonged postoperative ileus: A scoping review. World J Gastrointest Surg 2026; 18(4): 117318
URL: https://www.wjgnet.com/1948-9366/full/v18/i4/117318.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i4.117318

Shen DL, Wan L, Zhang XC, Fang YD, Jiang HC, Wei YC, Chen LF, Wu ZM, Ye CC, Pei C, Zhou H, Qian L. Repairing the impaired gut vascular barrier as a novel therapeutic target for prolonged postoperative ileus: A scoping review. World J Gastrointest Surg 2026; 18(4): 117318 [DOI: 10.4240/wjgs.v18.i4.117318]

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