T-LAK cell-originated protein kinase promotes tumorigenesis and metastasis of pancreatic neuroendocrine neoplasms via mitogen-activated protein kinase axis activation

doi:10.4240/wjgs.v18.i4.115798

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World Journal of Gastrointestinal Surgery

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1948-9366

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Apr 27, 2026; 18(4): 115798
Published online Apr 27, 2026. doi: 10.4240/wjgs.v18.i4.115798

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Figure 4 Anti-proliferative and anti-migratory roles of HI-TOPK-032 in BON-1 cells. A: Dose-response curve of HI-TOPK-032 treatment on BON-1 cell viability; B: IncuCyte analysis showing significant inhibition of BON-1 cell growth after 48 hours of HI-TOPK-032 treatment; C and D: Flow cytometry analysis of cell cycle distribution in HI-TOPK-032-intervened BON-1, showing G1/M phase prolongation and G2/M phase shortening; E: Flow cytometry-based apoptosis analysis of HI-TOPK-032-intervened BON-1; F: Apoptotic cell quantification following HI-TOPK-032 treatment; G: Transwell assay showing reduced migration and invasion of HI-TOPK-032-treated BON-1; H: Transwell migration assay quantifying the migration of HI-TOPK-032-treated BON-1. Matrigel invasion assay quantifying the invasion of HI-TOPK-032-treated BON-1. The mean ± SD is used for data representation. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001; ^dP < 0.0001. DMSO: Dimethyl sulfoxide.

Citation: Meng M, Chen Q, Yuan M, Guo X, Ren SQ, Yuan CH. T-LAK cell-originated protein kinase promotes tumorigenesis and metastasis of pancreatic neuroendocrine neoplasms via mitogen-activated protein kinase axis activation. World J Gastrointest Surg 2026; 18(4): 115798
URL: https://www.wjgnet.com/1948-9366/full/v18/i4/115798.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i4.115798

Meng M, Chen Q, Yuan M, Guo X, Ren SQ, Yuan CH. T-LAK cell-originated protein kinase promotes tumorigenesis and metastasis of pancreatic neuroendocrine neoplasms via mitogen-activated protein kinase axis activation. World J Gastrointest Surg 2026; 18(4): 115798 [DOI: 10.4240/wjgs.v18.i4.115798]

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