T-LAK cell-originated protein kinase promotes tumorigenesis and metastasis of pancreatic neuroendocrine neoplasms via mitogen-activated protein kinase axis activation

Figure 1 High expression of T-LAK cell-originated protein kinase in pancreatic neuroendocrine neoplasms with liver metastasis. A: Representative immunohistochemical staining of T-LAK cell-originated protein kinase in pancreatic neuroendocrine neoplasm (pNEN) tissue samples with and without liver metastasis; B: Quantification of T-LAK cell-originated protein kinase-positive cells in pNENs with and without liver metastasis. The mean ± SD is used for data representation; C: Kaplan-Meier survival curves for patients with pNENs with and without liver metastasis, showing a significantly shorter overall survival for the liver metastasis group. ^aP < 0.0001. HE: Hematoxylin-eosin staining; IHC: Immunohistochemistry; TOPK: T-LAK cell-originated protein kinase; pNEN: Pancreatic neuroendocrine neoplasm; pNENsLM: Pancreatic neuroendocrine neoplasms in the live metastasis; OS: Overall survival.