Incidence and predictors of gallstone disease after bariatric surgery in a Thai population

Table 2 Univariate analysis of risk factors of gallstone diseases after bariatric surgery

Risk factors	Gallstone (n = 47)	No gallstone (n = 196)	P value
Age (year), median (IQR)	30 (25, 38.5)	36 (29.8, 45)	0.005
Sex			0.665
Male	16 (34)	76 (38.8)
Female	31 (66)	120 (61.2)
Pre-op body weight (kg), median (IQR)	136 (116.5, 162.4)	122 (105.9, 146)	0.013
Pre-op height (cm), mean ± SD	162.2 ± 7.1	163.7 ± 9.4	0.304
Pre-op BMI (kg/m2), median (IQR)	51.9 (43.7, 59.2)	45.7 (41.5, 51.7)	0.187
Type of surgery			0.131
LSG	38 (80.9)	134 (68.4)
LRYGB	9 (19.1)	62 (31.6)
Diabetes mellitus			0.481
No	35 (74.5)	133 (67.9)
Yes	12 (25.5)	63 (32.1)
Dyslipidemia			0.792
No	22 (46.8)	85 (43.4)
Yes	25 (53.2)	111 (56.6)
Metabolic syndrome			0.6
No	47 (100)	190 (96.9)
Yes	0 (0)	6 (3.1)
Liver disease			0.592
No	41 (87.2)	177 (90.3)
Yes	6 (12.8)	19 (9.7)
Hematologic disease			0.381
No	44 (93.6)	190 (96.9)
Yes	3 (6.4)	6 (3.1)
OSA			0.571
No	19 (40.4)	68 (34.7)
Yes	28 (59.6)	128 (65.3)
Statin drug used			0.792
No	22 (46.8)	85 (43.4)
Yes	25 (53.2)	111 (56.6)
Pre-op cholesterol, median (IQR)	180 (155.5, 206)	186.5 (163, 213.2)	0.239
Pre-op triglyceride, median (IQR)	126 (105.5, 151)	124 (95, 168.2)	0.798
Pre-op HDL, median (IQR)	37.1 (34.3, 42)	42 (36.4, 50.8)	0.014
Pre-op LDL, median (IQR)	133.5 (40.7)	134 (38.5)	0.934
Pre-op FBS, median (IQR)	98 (87.5, 114.5)	96 (88.8, 113.2)	0.95
Pre-op Insulin, median (IQR)	25.6 (19.1, 30.4)	25.9 (15.6, 38.6)	0.587
Change of BMI (kg/m2), median (IQR)
At 6 months	11.9 (9.9, 14.4)	11.5 (9.2, 13.6)	0.272
At 12months	15 (12.3, 20.4)	14.2 (11.4, 17.8)	0.187
At 24 months, mean ± SD	15 ± 5.5	17.8 ± 8.2	0.118
Weight loss (kg), median (IQR)
At 6 months	31.5 (26.2, 37.6)	30.9 (24.2, 37.2)	0.504
At 12 months	38.8 (31.2, 54.2)	39 (30, 49)	0.247
At 24 months, mean ± SD	46 ± 22.8	40.2 ± 17.2	0.271
Weight loss (%), mean ± SD
At 6 months	24.7 ± 6.8	25 ± 5.9	0.766
At 12 months	32.6 ± 8.6	31.5 ± 7.2	0.446
At 24 months	33.3 ± 10.9	31.5 ± 10.1	0.546
Weight loss rate (kg/month), median (IQR)
At 6 months	5.2 (4.4, 6.3)	5.2 (4, 6.2)	0.504
At 12 months	3.2 (2.6, 4.5)	3.2 (2.5, 4.1)	0.247
At 24 months, mean ± SD	1.9 ± 1	1.7 ± 0.7	0.271

Data are presented as n (%) unless otherwise specified. IQR: Interquartile range; BMI: Body mass index; LRYGB: Laparoscopic Roux-en-Y gastric bypass; LSG: Laparoscopic sleeve gastrectomy; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; FBS: Fasting blood sugar; Pre-op: Preoperative; SD: Standard deviation.