Retrospective analysis cognitive function changes in elderly depressive patients after gastrointestinal tumor surgery and exploration of cholinergic mechanism

Table 3 Multivariate logistic regression analysis of post-operative cognitive dysfunction in older patients with depression after surgery for a gastrointestinal tumor

Variable (unit increment)	β	SE	Wald χ2	P value	OR	95%CI
Age (per 1 year)	0.13	0.05	6.76	0.009	1.14	1.03-1.26
Pre-operative HAMD score (per 1 point)	0.18	0.06	9.00	0.003	1.20	1.07-1.35
Duration of surgery (per 10 minutes)	0.09	0.03	9.00	0.003	1.01	1.00-1.02
Intra-operative anticholinergic use (yes vs no)	1.18	0.42	7.88	0.005	3.25	1.43-7.38
Post-operative IL-6 changes rate (per 10%)	0.05	0.02	6.25	0.012	1.05	1.01-1.09
Intra-operative blood loss (per 50 mL)	0.08	0.05	2.56	0.110	1.08	0.98-1.19
24-hour post-operative VAS score (per 1 point)	0.12	0.08	2.25	0.134	1.13	0.96-1.32
Post-operative infection (yes vs no)	0.65	0.48	1.83	0.176	1.92	0.75-4.91
Pre-operative IL-6 (per 1 pg/mL)	0.04	0.03	1.78	0.182	1.04	0.98-1.10
Post-operative TNF-α change rate (per 10%)	0.02	0.02	1.00	0.317	1.02	0.98-1.06
Pre-operative CHE (per 100 U/L)	-0.01	0.01	1.00	0.317	0.99	0.97-1.01
Post-operative CHE activity (per 100 U/L)	-0.02	0.02	1.00	0.317	0.98	0.94-1.02
Post-operative TNF-α (per 1 pg/mL)	0.01	0.02	0.25	0.617	1.01	0.97-1.05
Pre-operative TNF-α (per 1 pg/mL)	0.01	0.03	0.11	0.740	1.01	0.96-1.06
CHE change rate (per 1%)	-0.01	0.03	0.11	0.740	0.99	0.94-1.04
Constant	-20.85	5.23	15.89	< 0.001	0.00	-

HAMD: Hamilton Depression Rating Scale; VAS: Visual Analog Scale; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; CHE: Cholinesterase.