Prognostic value of a nomogram model for pancreatic cancer incorporating the systemic immune-inflammation and prognostic nutritional indices

Table 1 Baseline data

Clinicopathologic factors	Total number (n = 164)	Training cohort (n = 129)	External validation cohort (n = 35)	P value
Gender				0.022a
Male	89 (54.3)	76 (58.9)	13 (37.1)
Female	75 (45.7)	53 (41.1)	22 (62.9)
Age (years)				0.624
≤ 65	81 (49.4)	65 (50.4)	19 (54.3)
> 65	83 (50.6)	64 (49.6)	16 (45.7)
Underlying diseases				0.341
No	82 (50)	67 (51.9)	15 (42.9)
Yes	82 (50)	62 (48.1)	20 (57.1)
Surgical method				< 0.001a
Endoscopic surgery	32 (19.5)	16 (12.4)	16 (45.7)
Open surgery	132 (80.5)	113 (87.6)	19 (54.3)
Tumor location				0.804
Pancreatic body/tail	58 (35.4)	45 (34.9)	13 (37.1)
Pancreatic head	106 (64.6)	84 (65.1)	22 (62.9)
Tumor maximum diameter (cm)				0.301
≤ 3	81 (49.6)	61 (47.3)	20 (57.1)
> 3	83 (50.6)	68 (52.7)	15 (42.9)
T staging				0.543
T1-T2	120 (73.2)	93 (72.1)	27 (77.1)
T3-T4	42 (26.9)	36 (27.9)	8 (22.9)
N grouping				0.192
N0	100 (61.0)	82 (63.6)	18 (51.4)
N1-N2	64 (39.0)	47 (36.4)	17 (48.6)
TNM staging				0.771
I-II	144 (87.8)	114 (88.4)	30 (85.7)
III	20 (12.2)	15 (11.6)	5 (14.3)
Degree of tumor differentiation				0.871
Moderately or well-differentiated	105 (64.0)	83 (64.3)	22 (62.9)
Poorly differentiated	59 (36.0)	46 (35.7)	13 (37.1)
Surgical margins				0.343
Negative	158 (96.3)	123 (95.3)	35 (100.0)
Positive	6 (3.7)	6 (4.65)	0 (0.0)
Vascular tumor thrombus				0.072
No	81 (49.4)	59 (45.7)	22 (62.9)
Yes	83 (50.6)	70 (54.3)	13 (37.1)
Vascular/nerve invasion				0.381
No	20 (12.2)	14 (10.9)	6 (17.1)
Yes	144 (87.8)	115 (89.1)	29 (82.9)
Lymph node metastasis				0.139
No	102 (62.2)	84 (65.1)	18 (51.4)
Yes	62 (37.8)	45 (34.9)	17 (48.6)
Postoperative adjuvant chemotherapy				0.847
No	110 (67.1)	42 (32.6)	12 (34.3)
Yes	54 (32.9)	87 (67.4)	23 (65.7)
Recent postoperative complications				0.960
No	126 (76.8)	99 (76.7)	27 (77.1)
Yes	38 (23.2)	30 (23.3)	8 (22.9)
CEA (ng/mL)				0.322
≤ 5	123 (75.0)	99 (76.7)	24 (68.6)
> 5	41 (25.0)	30 (23.3)	11 (31.4)
CA19-9 (U/mL)				0.274
≤ 37	40 (24.4)	29 (22.5)	11 (31.4)
> 37	124 (75.6)	100 (77.5)	24 (68.6)
SII				0.011a
≤ 335.82	58 (35.4)	52 (40.3)	6 (17.1)
> 335.82	106 (64.6)	77 (59.7)	29 (82.9)
PNI				0.331
≤ 44.45	68 (41.5)	56 (43.4)	12 (34.3)
> 44.45	96 (58.5)	73 (56.6)	23 (65.7)

^aP < 0.05.

Data are presented as n (%). TNM: Tumor-node-metastasis; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; SII: Systemic immune inflammation index; PNI: Prognostic nutritional index.