Liver transplant and autoimmune liver diseases: An up-to-date review

doi:10.4240/wjgs.v18.i3.114915

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Mar 27, 2026; 18(3): 114915
Published online Mar 27, 2026. doi: 10.4240/wjgs.v18.i3.114915

Table 1 Emerging therapies for autoimmune hepatitis

Disease	Emerging therapies	Mechanism/target	Current evidence	Ref.
Autoimmune hepatitis	Rituximab	anti-CD20 monoclonal antibody → B-cell depletion	Positive results in refractory cases; clinical and biochemical improvement	Than et al[56], 2019
	Rituximab	anti-CD20 monoclonal antibody → B-cell depletion		Multicenter retrospective series, n = 22
	Zetomipzomib	Selective immunoproteasome inhibitor	Approximately 36% complete biochemical response in phase 2a trial	PORTOLA Trial (Kezar Life Sciences), 2025
	Zetomipzomib	Selective immunoproteasome inhibitor		Phase 2a, n = 24
	JKB-122	TLR4 antagonist	Biochemical and histological improvement in animal model; potentiates corticosteroid effect	Hsu et al[57], 2017
	JKB-122	TLR4 antagonist		Preclinical study (murine model)

TLR4: Toll-like receptor 4.

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Citation: Freire JPC, Lopes CF, Lima PHM, Feliciano LD, de Melo FF. Liver transplant and autoimmune liver diseases: An up-to-date review. World J Gastrointest Surg 2026; 18(3): 114915
URL: https://www.wjgnet.com/1948-9366/full/v18/i3/114915.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i3.114915

Freire JPC, Lopes CF, Lima PHM, Feliciano LD, de Melo FF. Liver transplant and autoimmune liver diseases: An up-to-date review. World J Gastrointest Surg 2026; 18(3): 114915 [DOI: 10.4240/wjgs.v18.i3.114915]

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