Development and validation of a risk prediction model for small intestinal mucosal injury in nonsteroidal anti-inflammatory drug users

doi:10.4240/wjgs.v18.i2.115830

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Feb 27, 2026; 18(2): 115830
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.115830

Table 3 Multivariate analysis identified the risk factors for small intestinal mucosal injury in patients using nonsteroidal anti-inflammatory drugs, n (%)

Characteristic	Univariate analysis		Multivariate analysis
Characteristic	OR (95%CI)	P value	OR (95%CI)	P value
Age	1.045 (1.010-1.082)	0.011	1.043 (1.003-1.084)	0.033
Smoking	2.126 (1.139-3.968)	0.018	2.352 (1.088-5.086)	0.030
BMI	1.174 (1.035-1.331)	0.013	1.176 (1.019-1.358)	0.026
PPI	2.009 (1.089-3.705)	0.025	2.099 (1.003-4.390)	0.049
TG	2.279 (1.232-4.215)	0.009	2.427 (1.196-4.924)	0.014
LDL	1.557 (1.107-2.188)	0.011	1.606 (1.089-2.367)	0.017

CI: Confidence interval; OR: Odds ratio; BMI: Body mass index; PPI: Proton pump inhibitor; TG: Triglyceride LDL: Low density lipoprotein; NSAID: Nonsteroidal anti-inflammatory drug.

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Citation: Zhao NH, Zhao LR, Yao J, Niu LY, Yang LJ, Lin YJ, Liu M. Development and validation of a risk prediction model for small intestinal mucosal injury in nonsteroidal anti-inflammatory drug users. World J Gastrointest Surg 2026; 18(2): 115830
URL: https://www.wjgnet.com/1948-9366/full/v18/i2/115830.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i2.115830

Zhao NH, Zhao LR, Yao J, Niu LY, Yang LJ, Lin YJ, Liu M. Development and validation of a risk prediction model for small intestinal mucosal injury in nonsteroidal anti-inflammatory drug users. World J Gastrointest Surg 2026; 18(2): 115830 [PMID: 41809323 DOI: 10.4240/wjgs.v18.i2.115830]

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