©Author(s) (or their employer(s)) 2026.
World J Gastrointest Surg. Feb 27, 2026; 18(2): 115830
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.115830
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.115830
Table 2 Comparison of clinical characteristics between nonsteroidal anti-inflammatory drug exposed patients with and without small intestinal mucosal injury, n (%)
| Variables | SIMI group (n = 114) | Non-SIMI group (n = 67) | P value |
| Sex, male | 70 (61.40) | 38 (56.72) | 0.535 |
| Age (years) | 60.64 ± 10.22 | 56.29 ± 9.48 | 0.009 |
| Smoking habit | 60 (52.63) | 23 (34.33) | 0.017 |
| Alcohol consumption | 36 (31.58) | 19 (28.36) | 0.649 |
| BMI (kg/m2) | 23.87 ± 2.67 | 22.73 ± 2.72 | 0.011 |
| Presenting symptoms | 0.627 | ||
| Abdominal pain | 15 (13.16) | 13 (19.40) | |
| Diarrhea | 2 (1.75) | 2 (2.99) | |
| Gastrointestinal bleeding | 91 (79.82) | 49 (73.13) | |
| Asymptomatic (health check-up) | 6 (5.26) | 3 (4.48) | |
| Indications for NSAID use | 0.644 | ||
| Cardiovascular disease | 77 (67.54) | 43 (64.18) | |
| Other | 37 (32.46) | 24 (35.82) | |
| NSAID types | 0.404 | ||
| Aspirin | 88 (77.19) | 48 (71.64) | |
| Other NSAIDs | 26 (22.81) | 19 (28.36) | |
| Prolonged use (≥ 3 months) | 96 (84.21) | 54 (80.60) | 0.533 |
| PPI | 69 (60.52) | 29 (43.28) | 0.025 |
| WBC (× 109/L) | 5.83 ± 2.07 | 5.95 ± 1.55 | 0.887 |
| Hb (g/L) | 89.69 ± 24.28 | 98.19 ± 37.49 | 0.412 |
| Alb (g/L) | 38.36 ± 5.50 | 39.73 ± 5.77 | 0.461 |
| TG (mmol/L) | 1.60 ± 0.62 | 1.34 ± 0.49 | 0.007 |
| LDL (mmol/L) | 3.03 (1.95, 3.51) | 2.36 (1.58, 2.97) | 0.004 |
| HDL (mmol/L) | 1.25 (1.07, 1.42) | 1.25 (1.05, 1.44) | 0.802 |
- Citation: Zhao NH, Zhao LR, Yao J, Niu LY, Yang LJ, Lin YJ, Liu M. Development and validation of a risk prediction model for small intestinal mucosal injury in nonsteroidal anti-inflammatory drug users. World J Gastrointest Surg 2026; 18(2): 115830
- URL: https://www.wjgnet.com/1948-9366/full/v18/i2/115830.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v18.i2.115830