Neurotrophin-3 rs1805149A>G variant in Hirschsprung disease: An investigative study

doi:10.4240/wjgs.v18.i2.114724

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Feb 27, 2026; 18(2): 114724
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.114724

Table 1 Demographics and characteristics of included patients and healthy control, n (%)

Variables	HSCR (n = 1470)	HC (n = 1473)	P value
Age (month)	8.37 ± 20.50	18.61 ± 19.75	< 0.05
< 2	745 (50.68)	1015 (68.91)
≥ 2	725 (49.32)	458 (31.09)
Sex			< 0.05
Male	1230 (83.67)	506 (34.35)
Female	240 (16.33)	967 (65.65)
HSCR subtype
S-HSCR	1033 (70.27)
L-HSCR	294 (20.00)
TCA	82 (5.58)
TIA	3 (0.2)

HC: Healthy control; HSCR: Hirschsprung disease; L-HSCR: Long segment Hirschsprung disease; S-HSCR: Short-segment Hirschsprung disease; TCA: Total colonic aganglionosis; TIA: Total intestine aganglionosis.

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Citation: Xu XG, Liu YQ, Lan ML, Liu F, Xia HM, Zeng JX. Neurotrophin-3 rs1805149A>G variant in Hirschsprung disease: An investigative study. World J Gastrointest Surg 2026; 18(2): 114724
URL: https://www.wjgnet.com/1948-9366/full/v18/i2/114724.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i2.114724

Xu XG, Liu YQ, Lan ML, Liu F, Xia HM, Zeng JX. Neurotrophin-3 rs1805149A>G variant in Hirschsprung disease: An investigative study. World J Gastrointest Surg 2026; 18(2): 114724 [PMID: 41809325 DOI: 10.4240/wjgs.v18.i2.114724]

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