Ligation of the intersphincteric fistula tract vs conventional surgery for anal fistula in Chinese patients

doi:10.4240/wjgs.v18.i2.113979

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Feb 27, 2026; 18(2): 113979
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.113979

Table 2 Summary of Evidence for ligation of the intersphincteric fistula tract vs conventional surgery-continuous outcomes

Outcome	Number of studies (RCTs)	LIFT group (n)	Conventional group (n)	Effect (95%CI)	Certainty of evidence	Reasons for downgrading
Dichotomous outcomes
Cure rate	39	1379/1762	1273/1764	RR = 1.08 (1.02-1.14)	Moderate	Serious risk of bias, inconsistency
Recurrence rate	23	96/1047	139/1048	RR = 0.61 (0.39-0.96)	Moderate	Serious risk of bias, inconsistency
Complication rate	31	75/1325	295/1326	RR = 0.25 (0.20-0.32)	Low	Serious risk of bias, imprecision
Overall clinical effectiveness	67	2568/2709	2221/2709	RR = 1.14 (1.11-1.17)	Moderate	Serious risk of bias, inconsistency
Continuous outcomes
Postoperative pain (VAS)	48	2086	2134	MD = -1.72 (-2.10 to -1.34)	Moderate	Serious risk of bias, inconsistency
Wound healing time (days)	61	2588	2640	MD = -8.45 (-9.73 to -7.17)	Moderate	Serious risk of bias, inconsistency
Anal function (score)	33	1300	1347	MD = -1.38 (-1.91 to -0.85)	Moderate	Serious risk of bias, inconsistency
Operative time (minutes)	41	1789	1811	MD = 3.71 (-0.60 to 8.02)	Moderate	Serious risk of bias, inconsistency

VAS: Visual Analog Scale; RCT: Randomized controlled trial; LIFT: Ligation of the intersphincteric fistula tract; CI: Confidence interval; RR: Relative risk; MD: Mean difference.

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Citation: Li X, Zhi CC, Wang XL, Zheng LH, Cheng YC. Ligation of the intersphincteric fistula tract vs conventional surgery for anal fistula in Chinese patients. World J Gastrointest Surg 2026; 18(2): 113979
URL: https://www.wjgnet.com/1948-9366/full/v18/i2/113979.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i2.113979

Li X, Zhi CC, Wang XL, Zheng LH, Cheng YC. Ligation of the intersphincteric fistula tract vs conventional surgery for anal fistula in Chinese patients. World J Gastrointest Surg 2026; 18(2): 113979 [PMID: 41809335 DOI: 10.4240/wjgs.v18.i2.113979]

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