Spatial immune cell architecture after gastric cancer surgery predicts prognosis

doi:10.4240/wjgs.v18.i2.113530

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Feb 27, 2026; 18(2): 113530
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.113530

Table 5 Key immune indicators for survival prognosis using multivariate Cox regression analysis

Variable	OS	DFS	P value
Variable	HR (95%CI)	HR (95%CI)	P value
CD8+ IM density > 220/mm²	0.52 (0.33-0.82)	0.61 (0.40-0.93)	0.004
CD8+/FoxP3+ ratio > 2.5	0.69 (0.45-1.06)	0.47 (0.29-0.76)	0.09
PD-L1+ tumor cells > 10%	2.15 (1.32-3.51)	1.84 (1.20-2.82)	0.001
CD68+CD163+ M2 TC > 85/mm²	1.43 (0.92-2.22)	1.72 (1.10-2.70)	0.112

IM: Invasive margin; FoxP3+: Forkhead box protein 3+; PD-L1: Programmed death ligand 1; TC: Tumor core; OS: Overall survival; DFS: Disease-free survival; HR: Hazard ratio; CI: Confidence interval.

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Citation: Yang HJ, Liu B. Spatial immune cell architecture after gastric cancer surgery predicts prognosis. World J Gastrointest Surg 2026; 18(2): 113530
URL: https://www.wjgnet.com/1948-9366/full/v18/i2/113530.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i2.113530

Yang HJ, Liu B. Spatial immune cell architecture after gastric cancer surgery predicts prognosis. World J Gastrointest Surg 2026; 18(2): 113530 [PMID: 41809321 DOI: 10.4240/wjgs.v18.i2.113530]

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