Spatial immune cell architecture after gastric cancer surgery predicts prognosis

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Feb 27, 2026; 18(2): 113530
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.113530

Table 4 Analysis of positive correlation factors for prognosis

Variable	Median/proportion	Five-year overall survival rate	P value
CD8+ T-cell density	248.5/mm²	High-density group 68.2% vs low-density group 42.1%	0.003
The ratio of CD8+ to FoxP3+	> 2.5
PD-L1+ tumor cell ratio	> 10%	Increase the risk of death
CD68+CD163+ M2 macrophages		Increase the risk of recurrence
IPS scoring system		AUC = 0.81

FoxP3+: Forkhead box protein 3+; PD-L1: Programmed death ligand 1; IPS: Immune prognosis scoring system.

Citation: Yang HJ, Liu B. Spatial immune cell architecture after gastric cancer surgery predicts prognosis. World J Gastrointest Surg 2026; 18(2): 113530
URL: https://www.wjgnet.com/1948-9366/full/v18/i2/113530.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i2.113530

Yang HJ, Liu B. Spatial immune cell architecture after gastric cancer surgery predicts prognosis. World J Gastrointest Surg 2026; 18(2): 113530 [PMID: 41809321 DOI: 10.4240/wjgs.v18.i2.113530]

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