Impact of dexmedetomidine preconditioning on analgesic and postoperative recovery in elderly patients undergoing laparoscopic cholecystectomy

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World Journal of Gastrointestinal Surgery

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1948-9366

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World J Gastrointest Surg. Feb 27, 2026; 18(2): 113525
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.113525

Table 2 Comparison of surgery features between two groups, n (%)/mean ± SD

Parameter	DEX conventional anesthesia group (n = 95)	DEX preconditioning anesthesia group (n = 87)	t/χ²	P value
Operative duration (minutes)	82.86 ± 12.43	82.25 ± 12.27	0.334	0.739
Anesthesia duration (minutes)	89.62 ± 13.84	89.84 ± 13.43	0.107	0.915
Intraoperative bleeding volume (mL)	14.44 ± 1.92	14.86 ± 2.24	1.351	0.178
Fluid replacement volume (mL)	746.25 ± 48.43	758.24 ± 50.91	1.628	0.105
Dose of anesthesia inducing drugs
Midazolam (mg)	2.12 ± 0.35	2.08 ± 0.32	0.711	0.478
Propofol (mg)	135.52 ± 20.25	132.75 ± 19.83	0.932	0.353
Sufentanil (μg)	24.38 ± 3.72	23.92 ± 3.69	0.847	0.398
Atracurium (mg)	12.25 ± 1.87	12.16 ± 1.78	0.344	0.731
Dose of anesthesia maintenance drugs
Propofol (mg)	452.38 ± 67.21	443.92 ± 65.84	0.856	0.393
Remifentanil (μg)	1286.54 ± 214.36	1262.47 ± 208.92	0.766	0.445
DEX (μg)	42.18 ± 6.32	41.75 ± 6.18	0.459	0.647
Times of atracurium is added	25 (26.32)	20 (22.99)	0.270	0.603

DEX: Dexmedetomidine.

Citation: Chen M, Chen FC, Pan Q, Liu ZH. Impact of dexmedetomidine preconditioning on analgesic and postoperative recovery in elderly patients undergoing laparoscopic cholecystectomy. World J Gastrointest Surg 2026; 18(2): 113525
URL: https://www.wjgnet.com/1948-9366/full/v18/i2/113525.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i2.113525

Chen M, Chen FC, Pan Q, Liu ZH. Impact of dexmedetomidine preconditioning on analgesic and postoperative recovery in elderly patients undergoing laparoscopic cholecystectomy. World J Gastrointest Surg 2026; 18(2): 113525 [PMID: 41809358 DOI: 10.4240/wjgs.v18.i2.113525]

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