Association between type 2 diabetes mellitus and colorectal adenoma: A retrospective study with insights into Wnt/β-Catenin/TCF7L2 pathway activation

doi:10.4240/wjgs.v18.i2.113476

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Feb 27, 2026; 18(2): 113476
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.113476

Table 5 Average optical value analysis of each experimental group, mean ± SD

AO	A + D group (n = 20)	A + ND group (n = 20)	NA + ND group (n = 20)
β-catenin	0.118 ± 0.027	0.094 ± 0.028^a	0.045 ± 0.02^a
TCF7 L2	0.063 ± 0.029	0.030 ± 0.012^b	0.023 ± 0.010^b
Ki67	0.078 ± 0.028	0.038 ± 0.014^c	0.018 ± 0.014^c

^aP < 0.05, the expression of β-catenin in A + D group was higher than that in A + ND group and control group.

^bP < 0.05, the expression of transcription factor 7 like 2 in A + D group was higher than that in A + ND group and control group.

^cP < 0.05, the expression of Ki67 in A + D group was higher than that in A + ND group and control group.

Image-Pro Plus version 6.0 software was used to select images with the same color, and the same brown-yellow color was used as the unified standard to judge the positivity of all photos. The positive integrated optical density value and the pixel area of the tissue were analyzed for each photo, and the average optical value was calculated. The higher the average optical value, the higher the positive expression level. AO: Average optical; TCF7 L2: Transcription factor 7 like 2.

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Citation: Gui SY, Tang RX, Huang X, Yang GQ, Yang J. Association between type 2 diabetes mellitus and colorectal adenoma: A retrospective study with insights into Wnt/β-Catenin/TCF7L2 pathway activation. World J Gastrointest Surg 2026; 18(2): 113476
URL: https://www.wjgnet.com/1948-9366/full/v18/i2/113476.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i2.113476

Gui SY, Tang RX, Huang X, Yang GQ, Yang J. Association between type 2 diabetes mellitus and colorectal adenoma: A retrospective study with insights into Wnt/β-Catenin/TCF7L2 pathway activation. World J Gastrointest Surg 2026; 18(2): 113476 [PMID: 41809341 DOI: 10.4240/wjgs.v18.i2.113476]

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