Association between type 2 diabetes mellitus and colorectal adenoma: A retrospective study with insights into Wnt/β-Catenin/TCF7L2 pathway activation

doi:10.4240/wjgs.v18.i2.113476

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Feb 27, 2026; 18(2): 113476
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.113476

Table 4 Analysis of carcinoembryonic antigen and insulin-like growth factor-1 levels in each experimental group, median (interquartile rage)/mean ± SD

	A + D group (n = 20)	A + ND group (n = 20)	NA + ND group (n = 10)
CEA (ng/mL)	3.63 (2.46-4.85)	2.19 (1.35-2.98)^a	1.41 (0.90-2.11)^a
IGF-1 (ng/mL)	142.53 ± 16.38	123.70 ± 11.32^b	102.52 ± 8.98^b

^aP < 0.05, the carcinoembryonic antigen level in A + D group was higher than that in A + ND group and control group.

^bP < 0.05, the insulin-like growth factor-1 level in A + D group was higher than that in A + ND group and control group.

CEA: Carcinoembryonic antigen; IGF-1: Insulin-like growth factor-1.

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Citation: Gui SY, Tang RX, Huang X, Yang GQ, Yang J. Association between type 2 diabetes mellitus and colorectal adenoma: A retrospective study with insights into Wnt/β-Catenin/TCF7L2 pathway activation. World J Gastrointest Surg 2026; 18(2): 113476
URL: https://www.wjgnet.com/1948-9366/full/v18/i2/113476.htm
DOI: https://dx.doi.org/10.4240/wjgs.v18.i2.113476

Gui SY, Tang RX, Huang X, Yang GQ, Yang J. Association between type 2 diabetes mellitus and colorectal adenoma: A retrospective study with insights into Wnt/β-Catenin/TCF7L2 pathway activation. World J Gastrointest Surg 2026; 18(2): 113476 [PMID: 41809341 DOI: 10.4240/wjgs.v18.i2.113476]

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