Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma

Figure 1 Histologic features of xanthogranulomatous cholecystitis. A: Low-power view showing an irregularly and unevenly thickened gallbladder wall in a case of xanthogranulomatous cholecystitis; B: The perimuscular soft tissues show a dense inflammatory infiltrate predominantly composed of numerous foamy histiocytes and lymphocytes. No Michaelis-Gutmann bodies, which are characteristic of malakoplakia, are identified; C: In addition to the inflammatory infiltrate, fibroblasts and fibrotic tissue displaying a vaguely storiform pattern are present (right side), potentially posing diagnostic challenges with neoplastic diseases; D: CD68 (PGM1) immunohistochemical staining highlights the predominant histiocytic component.