Acquired hemophilia A following choledochal cyst excision - highlighting postoperative bile leak and infection as potential triggers: A case report

Figure 2 Timeline of changes in coagulation indices. A-H: Activated partial thromboplastin time (APTT) gradually decreased from 58.4 seconds at the time of admission to 26.8 seconds on April 12, 2024, and the APTT ratio returned to 0.99. Factor VIII (FVIII) activity continuously increased from 0.9% to 138.9% on April 23, 2024. The FVIII inhibitor titer decreased from 2.08 to 0.85 BU/mL and eventually turned negative. D-dimer and fibrin degradation product levels decreased from significantly elevated levels to normal ranges, and the patient’s coagulation function stabilized. FDP: Fibrin degradation product; PT: Prothrombin time; VIII: Factor VIII; APTT: Activated partial thromboplastin time; PT-INR: Prothrombin time-international normalized ratio; TT: Thrombin time.