Impact of perioperative Helicobacter pylori eradication therapy on long-term survival after distal gastrectomy for gastric cancer

Table 9 Multivariate Cox regression analysis of factors associated with overall survival and disease-free survival

Variable	β	SE	Wald χ2	P value	HR	95%CI
OS
Eradication (yes vs no)	-0.598	0.285	4.405	0.036	0.551	0.310-0.964
Age (per year)	0.032	0.018	3.160	0.075	1.036	0.993-1.075
Sex (male vs female)	0.128	0.248	0.267	0.606	1.143	0.701-1.853
pTNM stage (III vs I-II)	0.852	0.314	7.361	0.007	2.347	1.274-4.340
Differentiation (poor vs well/moderate)	0.318	0.242	1.728	0.189	1.375	0.863-2.211
Lymphovascular invasion (yes vs no)	0.452	0.256	3.117	0.078	1.571	0.955-2.592
DFS
Eradication (yes vs no)	-0.511	0.252	4.113	0.043	0.604	0.362-0.984
Age (per year)	0.018	0.017	1.121	0.290	1.025	0.996-1.050
Sex (male vs female)	0.146	0.228	0.410	0.522	1.166	0.741-1.813
pTNM stage (III vs I-II)	0.824	0.278	8.787	0.003	2.287	1.327-3.931
Differentiation (poor vs well/moderate)	0.262	0.218	1.444	0.230	1.306	0.859-1.992
Lymphovascular invasion (yes vs no)	0.378	0.234	2.610	0.106	1.462	0.926-2.315

β: Regression coefficient; HR: Hazard ratio; CI: Confidence interval; OS: Overall survival; DFS: Disease-free survival; pTNM: Pathological tumor-node-metastasis.