Impact of perioperative Helicobacter pylori eradication therapy on long-term survival after distal gastrectomy for gastric cancer

doi:10.4240/wjgs.124292

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Nov 27, 2026; 18(11): 124292
Published online Nov 27, 2026. doi: 10.4240/wjgs.124292

Table 8 Comparison of long-term oncologic outcomes between the two groups, n (%)

Parameters	Non-eradication group (n = 143)	Eradication group (n = 128)	χ²	P value
5-year OS rate (%)	80.42	91.41	6.618	0.010
All-cause death	28 (19.58)	11 (8.59)
5-year DFS rate (%)	72.73	85.94	7.097	0.008
Recurrence or metastasis	39 (27.27)	18 (14.06)
Local recurrence	14 (9.79)	6 (4.69)
Regional recurrence	10 (6.99)	5 (3.91)
Distant metastasis	15 (10.49)	7 (5.47)
Metachronous gastric cancer	11 (7.69)	2 (1.56)	5.557	0.018
Gastric cancer-specific death	22 (15.38)	8 (6.25)	5.725	0.017

OS: Overall survival; DFS: Disease-free survival.

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Citation: Shi RC, Jin D, Su D, Yang XT, Wang X, Hao JF, Yang ZW. Impact of perioperative Helicobacter pylori eradication therapy on long-term survival after distal gastrectomy for gastric cancer. World J Gastrointest Surg 2026; 18(11): 124292
URL: https://www.wjgnet.com/1948-9366/full/v18/i11/124292.htm
DOI: https://dx.doi.org/10.4240/wjgs.124292

Shi RC, Jin D, Su D, Yang XT, Wang X, Hao JF, Yang ZW. Impact of perioperative Helicobacter pylori eradication therapy on long-term survival after distal gastrectomy for gastric cancer. World J Gastrointest Surg 2026; 18(11): 124292 [DOI: 10.4240/wjgs.124292]

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