Impact of perioperative Helicobacter pylori eradication therapy on long-term survival after distal gastrectomy for gastric cancer

doi:10.4240/wjgs.124292

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World Journal of Gastrointestinal Surgery

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1948-9366

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Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Nov 27, 2026; 18(11): 124292
Published online Nov 27, 2026. doi: 10.4240/wjgs.124292

Table 7 Comparison of adjuvant chemotherapy completion (stage II/III patients), n (%)/mean ± SD

Parameters	Non-eradication group (n = 143)	Eradication group (n = 128)	t/χ²	P value
Chemotherapy regimen			0.319	0.853
XELOX	59 (56.19)	48 (53.33)
SOX	38 (36.19)	36 (40.00)
Other	8 (7.62)	6 (6.67)
Chemotherapy delay	29 (28.71)	14 (15.56)	4.103	0.043
Dose reduction	24 (23.76)	10 (11.11)	4.645	0.031
Completed cycles	5.68 ± 1.48	6.22 ± 1.16	2.832	0.005
Relative dose intensity (%)	85.28 ± 10.86	89.54 ± 7.88	3.165	0.002
Planned cycle completion	67 (66.34)	74 (82.22)	8.205	0.004
Discontinuation due to adverse events	20 (19.80)	8 (8.89)	4.067	0.044

XELOX: Capecitabine plus oxaliplatin; SOX: S-1 plus oxaliplatin.

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Citation: Shi RC, Jin D, Su D, Yang XT, Wang X, Hao JF, Yang ZW. Impact of perioperative Helicobacter pylori eradication therapy on long-term survival after distal gastrectomy for gastric cancer. World J Gastrointest Surg 2026; 18(11): 124292
URL: https://www.wjgnet.com/1948-9366/full/v18/i11/124292.htm
DOI: https://dx.doi.org/10.4240/wjgs.124292

Shi RC, Jin D, Su D, Yang XT, Wang X, Hao JF, Yang ZW. Impact of perioperative Helicobacter pylori eradication therapy on long-term survival after distal gastrectomy for gastric cancer. World J Gastrointest Surg 2026; 18(11): 124292 [DOI: 10.4240/wjgs.124292]

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