Expression and role of the long noncoding RNA Linc00909 in chemoradiotherapy for colorectal cancer

Table 3 Univariate and multivariate Cox regression analyses of disease-free survival in the 196 patients with colorectal cancer

Variable	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Sex, male/female	0.889	0.496-1.596	0.694
Age	1.004	0.980-1.029	0.754
American Society of Anesthesiologists score	0.971	0.563-1.674	0.916
Postoperative hospital stay	0.984	0.938-1.033	0.516
Tumor size	0.949	0.829-1.087	0.451
Histopathology	0.855	0.400-1.827	0.687
Tumor location			0.686
Ascending colon	Reference	Reference
Transverse colon	0.690	0.178-2.667	0.590
Descending colon	0.656	0.136-3.160	0.599
Sigmoid colon	0.952	0.354-2.555	0.922
Rectum	1.312	0.571-3.013	0.522
Tumor differentiation	0.992	0.506-1.945	0.981
Gross type	0.466	0.228-0.952	0.036	0.681	0.315-1.476	0.331
Pathological T stage	2.202	1.374-3.528	0.001	1.565	0.945-2.593	0.082
Pathological N stage	1.941	1.389-2.712	< 0.001	1.127	0.688-1.846	0.636
Lymph nodes retrieved	0.987	0.957-1.004	0.110
Metastatic lymph nodes	1.115	1.059-1.174	< 0.001	1.069	0.986-1.159	0.104
Neural invasion	1.827	1.002-3.333	0.049	1.365	0.703-2.650	0.357
Vascular invasion	2.164	1.009-4.640	0.047	1.450	0.613-3.429	0.397
Linc00909 expression	5.643	2.638-12.070	< 0.001	5.335	2.467-11.536	< 0.001

Univariate analysis was performed for each variable; variables with P < 0.05 in the univariate analysis were entered into the multivariate Cox proportional hazards model (using forward selection). Bold P values indicate statistical significance (P < 0.05). High Linc00909 expression was used as the reference category. CI: Confidence interval; HR: Hazard ratio.