Expression and role of the long noncoding RNA Linc00909 in chemoradiotherapy for colorectal cancer

Table 2 Univariate and multivariate Cox regression analyses of overall survival in the 196 patients with colorectal cancer

Variable	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Sex, male/female	1.176	0.487-2.838	0.719
Age	0.998	0.962-1.036	0.918
American Society of Anesthesiologists	1.092	0.471-2.530	0.837
Postoperative hospital stay	1.011	0.959-1.065	0.695
Tumor size	1.070	0.889-1.287	0.474
Histopathology	0.459	0.106-1.980	0.296
Tumor location			0.686
Ascending colon	Reference	Reference
Transverse colon	1.802	0.253-12.806	0.556
Descending colon	1.168	0.106-12.901	0.899
Sigmoid colon	1.667	0.305-9.105	0.555
Rectum	2.028	0.449-9.152	0.358
Tumor differentiation	0.358	0.083-1.544	0.169
Gross type	0.112	0.015-0.827	0.032	0.188	0.025-1.427	0.106
Pathological T stage	2.928	1.372-6.246	0.005	1.371	0.616-3.053	0.439
Pathological N stage	2.293	1.369-3.841	0.002	1.755	0.987-3.120	0.055
Lymph nodes retrieved	0.982	0.946-1.018	0.326
Metastatic lymph nodes	1.083	0.996-1.178	0.062
Neural invasion	3.775	1.570-9.076	0.003	3.109	1.245-7.764	0.015
Vascular invasion	0.524	0.070-3.925	0.529
Linc00909 expression	4.518	1.510-13.522	0.007	5.067	1.629-15.765	0.005

Univariate analysis was performed for each variable; variables with P < 0.05 in the univariate analysis were entered into the multivariate Cox proportional hazards model (using forward selection). Bold P values indicate statistical significance (P < 0.05). The reference group for Linc00909 expression was low expression. CI: Confidence interval; HR: Hazard ratio.