Minimally invasive rectal cancer surgery after neoadjuvant therapy in selected elderly and frail patients: A single-center real-world experience

doi:10.4240/wjgs.123538

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Oct 27, 2026; 18(10): 123538
Published online Oct 27, 2026. doi: 10.4240/wjgs.123538

Table 3 Postoperative outcomes stratified by age and frailty, n (%)

Variable	Age ≥ 80 years (n = 23)	Age < 80 years (n = 119)	P value (age)	Frail (n = 16)	Non-frail (n = 126)	P value (frail)
ICU admission	12 (52.2)	53 (44.9)	-
ICU stay (days), median	1.5	1	-
Medical complications	14 (60.9)	41 (34.5)	0.017	6 (37.5)	49 (38.9)	0.914
Surgical complications	6 (26.1)	17 (14.3)	0.165	4 (25.0)	19 (15.1)	0.165
Clavien-Dindo ≥ 3	7 (30.4)	7 (5.9)	0.002	3 (21.4)	13 (10.2)	0.205
Anastomotic leak	6 (26.1)	20 (16.8)	0.292	4 (25.0)	22 (17.5)	0.292
Reintervention	2 (8.7)	7 (5.9)	0.612	2 (12.5)	7 (5.6)	0.612
Length of stay (days), median (IQR)	10 (8.5)	8 (5.0)	0.044
Length of stay (days), range	6-27	5-33
90-day mortality	1 (4.3)	0 (0)	0.162	0 (0)	1 (0.7)	-
Stoma reversal	2 (8.7)	64 (54.7)	< 0.001	7 (43.8)	59 (47.6)	0.704

ICU: Included intensive care unit; IQR: Interquartile range.

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Citation: Zucchini V, Solaini L, Avanzolini A, Ercolani G. Minimally invasive rectal cancer surgery after neoadjuvant therapy in selected elderly and frail patients: A single-center real-world experience. World J Gastrointest Surg 2026; 18(10): 123538
URL: https://www.wjgnet.com/1948-9366/full/v18/i10/123538.htm
DOI: https://dx.doi.org/10.4240/wjgs.123538

Zucchini V, Solaini L, Avanzolini A, Ercolani G. Minimally invasive rectal cancer surgery after neoadjuvant therapy in selected elderly and frail patients: A single-center real-world experience. World J Gastrointest Surg 2026; 18(10): 123538 [DOI: 10.4240/wjgs.123538]

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