Efficacy and safety of Huazhuojiedu decoction for gastric precancerous lesions after endoscopic submucosal dissection

doi:10.4240/wjgs.122120

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World Journal of Gastrointestinal Surgery

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1948-9366

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Oct 27, 2026; 18(10): 122120
Published online Oct 27, 2026. doi: 10.4240/wjgs.122120

Table 11 Cox regression analysis of factors affecting precancerous lesion progression

Variable	Univariate HR (95%CI)	Univariate P	Multivariate HR (95%CI)	Multivariate P
Age (≥ 65 vs < 65)	1.682 (0.886-3.194)	0.112	-	-
Gender (male vs female)	1.124 (0.568-2.224)	0.736	-	-
BMI (≥ 24 vs < 24)	0.892 (0.456-1.745)	0.738	-	-
Smoking (yes vs no)	1.524 (0.792-2.932)	0.208	-	-
Drinking (yes vs no)	1.436 (0.724-2.848)	0.302	-	-
Diabetes (yes vs no)	1.386 (0.624-3.078)	0.422	-	-
Hypertension (yes vs no)	1.245 (0.612-2.534)	0.546	-	-
Poorly differentiation (yes vs no)	1.724 (0.786-3.782)	0.174	-	-
HGIN (yes vs no)	3.856 (1.892-7.862)	< 0.001	3.286 (1.524-7.086)	0.002
Score ≥ 6 (yes vs no)	2.724 (1.386-5.352)	0.004	2.458 (1.182-5.112)	0.016
Cardia (yes vs no)	1.856 (0.824-4.182)	0.135	-	-
HJD treatment (yes vs no)	0.362 (0.172-0.762)	0.007	0.385 (0.178-0.832)	0.015

HR: Hazard ratio; BMI: Body mass index; HGIN: High-grade intraepithelial neoplasia; HJD: Huazhuojiedu decoction.

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Citation: Si YJ, Ren NN, Wang JY, Hao XY, Wang ZJ, Li HX, Ge XF, An J, Shi XS, Shen T, Liang J, Ouyang XJ, Wang XY, Wang YG. Efficacy and safety of Huazhuojiedu decoction for gastric precancerous lesions after endoscopic submucosal dissection. World J Gastrointest Surg 2026; 18(10): 122120
URL: https://www.wjgnet.com/1948-9366/full/v18/i10/122120.htm
DOI: https://dx.doi.org/10.4240/wjgs.122120

Si YJ, Ren NN, Wang JY, Hao XY, Wang ZJ, Li HX, Ge XF, An J, Shi XS, Shen T, Liang J, Ouyang XJ, Wang XY, Wang YG. Efficacy and safety of Huazhuojiedu decoction for gastric precancerous lesions after endoscopic submucosal dissection. World J Gastrointest Surg 2026; 18(10): 122120 [DOI: 10.4240/wjgs.122120]

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