Efficacy and safety of Huazhuojiedu decoction for gastric precancerous lesions after endoscopic submucosal dissection

doi:10.4240/wjgs.122120

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Oct 27, 2026; 18(10): 122120
Published online Oct 27, 2026. doi: 10.4240/wjgs.122120

Table 1 Comparison of baseline characteristics between two groups, n (%)/mean ± SD

Variable	Observation (n = 119)	Control (n = 117)	χ²/t/Z	P value
Gender - male	71 (59.7)	67 (57.3)	0.186	0.666
Gender - female	48 (40.3)	50 (42.7)	-	-
Age (years)	58.34 ± 8.72	57.86 ± 9.15	0.412	0.681
BMI (kg/m²)	23.18 ± 2.86	23.42 ± 2.91	-0.639	0.523
Smoking history	42 (35.3)	38 (32.5)	0.204	0.651
Drinking history	35 (29.4)	31 (26.5)	0.249	0.618
Diabetes history	18 (15.1)	15 (12.8)	0.260	0.610
Hypertension history	32 (26.9)	29 (24.8)	0.137	0.711
Staging - carcinoma in situ	98 (82.4)	95 (81.2)	0.089	0.766
Staging - intramucosal carcinoma	21 (17.6)	22 (18.8)	-	-
Differentiation - well-moderate	103 (86.6)	99 (84.6)	0.324	0.569
Differentiation - poorly differentiated	16 (13.4)	18 (15.4)	-	-
Atrophic gastritis	119 (100.0)	117 (100.0)	-	-
Intestinal metaplasia	108 (90.8)	104 (88.9)	0.225	0.635
LGIN	45 (37.8)	42 (35.9)	0.093	0.760
HGIN	12 (10.1)	14 (12.0)	0.212	0.645
Location - antrum	52 (43.7)	54 (46.2)	0.892	0.827
Location - body	35 (29.4)	31 (26.5)	-	-
Location - angle	23 (19.3)	24 (20.5)	-	-
Location - cardia	9 (7.6)	8 (6.8)	-	-
H. pylori infection	68 (57.1)	64 (54.7)	0.141	0.707
Pre-treatment TCM score	18.52 ± 5.36	18.21 ± 5.48	0.439	0.661

BMI: Body mass index; LGIN: Low-grade intraepithelial neoplasia; HGIN: High-grade intraepithelial neoplasia; TCM: Traditional Chinese medicine; H. pylori: Helicobacter pylori.

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Citation: Si YJ, Ren NN, Wang JY, Hao XY, Wang ZJ, Li HX, Ge XF, An J, Shi XS, Shen T, Liang J, Ouyang XJ, Wang XY, Wang YG. Efficacy and safety of Huazhuojiedu decoction for gastric precancerous lesions after endoscopic submucosal dissection. World J Gastrointest Surg 2026; 18(10): 122120
URL: https://www.wjgnet.com/1948-9366/full/v18/i10/122120.htm
DOI: https://dx.doi.org/10.4240/wjgs.122120

Si YJ, Ren NN, Wang JY, Hao XY, Wang ZJ, Li HX, Ge XF, An J, Shi XS, Shen T, Liang J, Ouyang XJ, Wang XY, Wang YG. Efficacy and safety of Huazhuojiedu decoction for gastric precancerous lesions after endoscopic submucosal dissection. World J Gastrointest Surg 2026; 18(10): 122120 [DOI: 10.4240/wjgs.122120]

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