Correlation between pathological response to neoadjuvant immunotherapy and long-term survival in locally advanced rectal cancer: A real-world study

doi:10.4240/wjgs.121168

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World Journal of Gastrointestinal Surgery

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1948-9366

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World J Gastrointest Surg. Oct 27, 2026; 18(10): 121168
Published online Oct 27, 2026. doi: 10.4240/wjgs.121168

Table 5 Multivariate analysis of factors affecting long-term survival in patients with locally advanced rectal cancer

Variable	Coding	DFS (HR, 95%CI)	P value (DFS)	OS (HR, 95%CI)	P value (OS)
Maximum tumor diameter (cm)	> 4.5 = 1, ≤ 4.5 = 0	1.521 (0.802-2.885)	0.198	1.485 (0.752-2.932)	0.256
Preoperative imaging T stage	T4 = 1, T3 = 0	2.157 (1.203-3.876)	0.009	1.892 (0.985-3.635)	0.056
Preoperative imaging N stage	N2 = 1, N0-1 = 0	2.841 (1.562-5.167)	0.001	3.012 (1.583-5.731)	0.001
Treatment regimen	Immunotherapy monotherapy = 1, combination immunotherapy = 0	1.452 (0.782-2.695)	0.235	1.385 (0.721-2.662)	0.321
Pathological response	Non-MPR = 1, MPR/pCR = 0	0.324 (0.186-0.564)	< 0.001	0.289 (0.145-0.576)	< 0.001

MPR: Major pathological response; pCR: Pathological complete response; DFS: Disease-free survival; HR: Hazard ratio; CI: Confidence interval; OS: Overall survival.

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Citation: Zhang K, Li ZJ. Correlation between pathological response to neoadjuvant immunotherapy and long-term survival in locally advanced rectal cancer: A real-world study. World J Gastrointest Surg 2026; 18(10): 121168
URL: https://www.wjgnet.com/1948-9366/full/v18/i10/121168.htm
DOI: https://dx.doi.org/10.4240/wjgs.121168

Zhang K, Li ZJ. Correlation between pathological response to neoadjuvant immunotherapy and long-term survival in locally advanced rectal cancer: A real-world study. World J Gastrointest Surg 2026; 18(10): 121168 [DOI: 10.4240/wjgs.121168]

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