Correlation between pathological response to neoadjuvant immunotherapy and long-term survival in locally advanced rectal cancer: A real-world study

doi:10.4240/wjgs.121168

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Oct 27, 2026; 18(10): 121168
Published online Oct 27, 2026. doi: 10.4240/wjgs.121168

Table 3 Comparison of survival outcomes between patients with pathological remission, n (%)

Response	Number of patients	Recurrence or metastasis	Deaths	1-year DFS (%)	1-year OS (%)	Log-rank χ² (DFS)	P value (DFS)	Log-rank χ² (OS)	P value (OS)
pCR group (TRG 0)	30	1 (3.3)	0 (0.0)	96.7	100.0	28.652	< 0.001	25.321	< 0.001
MPR group (TRG 1)	30	4 (13.3)	2 (6.7)	88.3	95.0
Non-MPR group (TRGs 2 and 3)	70	14 (20.0)	8 (11.4)	65.0	77.5
Total	130	19 (14.6)	10 (7.7)	85.4	92.3

pCR: Pathological complete response; TRG: Tumor regression grade; MPR: Major pathological response; DFS: Disease-free survival; OS: Overall survival.

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Citation: Zhang K, Li ZJ. Correlation between pathological response to neoadjuvant immunotherapy and long-term survival in locally advanced rectal cancer: A real-world study. World J Gastrointest Surg 2026; 18(10): 121168
URL: https://www.wjgnet.com/1948-9366/full/v18/i10/121168.htm
DOI: https://dx.doi.org/10.4240/wjgs.121168

Zhang K, Li ZJ. Correlation between pathological response to neoadjuvant immunotherapy and long-term survival in locally advanced rectal cancer: A real-world study. World J Gastrointest Surg 2026; 18(10): 121168 [DOI: 10.4240/wjgs.121168]

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