Risk factors for anastomotic leakage after radical colorectal cancer surgery and its impact on prognosis: Clinical education research

Table 6 Cox regression analysis of factors affecting disease-free survival

Variable	Univariate HR	Univariate 95%CI	Univariate P value	Multivariate HR	Multivariate 95%CI	Multivariate P value
Age (≥ 65 years vs < 65 years)	1.264	0.802-1.992	0.246	-	-	-
Gender (male vs female)	1.128	0.724-1.758	0.558	-	-	-
BMI (≥ 25 kg/m² vs < 25 kg/m²)	1.248	0.802-1.942	0.278	-	-	-
TNM stage III vs I-II	2.624	1.786-3.854	< 0.001	2.248	1.526-3.312	< 0.001
Poor differentiation	1.924	1.286-2.878	0.001	1.686	1.118-2.544	0.013
Vascular invasion	2.024	1.368-2.994	< 0.001	1.782	1.188-2.672	0.005
Anastomotic leakage (yes vs no)	2.462	1.586-3.822	< 0.001	2.048	1.312-3.198	0.002
Adjuvant chemo delay (yes vs no)	1.824	1.186-2.806	0.006	1.624	1.048-2.518	0.030
Preop albumin < 35 g/L	1.624	1.028-2.564	0.038	-	-	-
Tumor location (rectum vs colon)	1.248	0.842-1.848	0.268	-	-	-

BMI: Body mass index; HR: Hazard ratio.