Risk factors for anastomotic leakage after radical colorectal cancer surgery and its impact on prognosis: Clinical education research

Table 4 Clinical grade, manifestations, and management of anastomotic leakage cases (n = 22), n (%)/mean ± SD/mean (interquartile range)

Characteristic	Grade A (n = 8)	Grade B (n = 10)	Grade C (n = 4)	Total (n = 22)	P value
Onset time (days)	6 (4-9)	8 (5-12)	5 (3-7)	7 (4-11)	0.312
Clinical manifestations
Fever	4 (50.0)	7 (70.0)	4 (100.0)	15 (68.2)	0.046
Abdominal pain	2 (25.0)	7 (70.0)	4 (100.0)	13 (59.1)	0.004
Feculent drainage	1 (12.5)	6 (60.0)	4 (100.0)	11 (50.0)	0.002
Peritonitis signs	0 (0.0)	2 (20.0)	4 (100.0)	6 (27.3)	0.001
Management
Conservative treatment	8 (100.0)	4 (40.0)	0 (0.0)	12 (54.5)	< 0.001
Interventional drainage	0 (0.0)	4 (40.0)	2 (50.0)	6 (27.3)	< 0.001
Surgical re-intervention	0 (0.0)	2 (20.0)	2 (50.0)	4 (18.2)	< 0.001
ICU admission	0 (0.0)	2 (20.0)	3 (75.0)	5 (22.7)	< 0.001
Hospital stay (days)	13.6 ± 3.4	25.8 ± 7.2	40.4 ± 13.8	24.2 ± 12.4	< 0.001
30-day mortality	0 (0.0)	0 (0.0)	1 (25.0)	1 (4.5)	0.021

ICU: Intensive care unit.