Patterns and risk factors of early recurrence after radical resection for intrahepatic cholangiocarcinoma

Table 5 Survival outcomes according to recurrence status, %

Group	n	OS, median (95%CI), months	1-year OS	3-year OS	5-year OS	P value
Overall cohort	386	31.2 (27.8-34.6)	82.4	42.7	28.3
By recurrence status
No recurrence	149	58.7 (52.3-65.1)	96.6	71.8	54.2	Reference
Early recurrence	178	18.5 (16.2-20.8)	71.3	18.0	5.1	< 0.001
Late recurrence	59	42.3 (36.7-47.9)	100	52.5	23.7	< 0.001
Post-recurrence survival
Early recurrence	178	9.8 (8.4-11.2)	38.2	8.4	2.8	Reference
Late recurrence	59	18.6 (14.9-22.3)	71.2	25.4	10.2	< 0.001
By treatment of recurrence
Repeat resection/RFA	34	28.3 (21.7-34.9)	82.4	35.3	17.6	Reference
Locoregional therapy	67	19.2 (15.8-22.6)	71.6	19.4	7.5	0.012
Systemic chemotherapy	112	12.4 (10.1-14.7)	51.8	8.9	0	< 0.001
Best supportive care	24	3.1 (2.2-4.0)	4.2	0	0	< 0.001

RFA: Radiofrequency ablation; CI: Confidence interval; OS: Overall survival.