Patterns and risk factors of early recurrence after radical resection for intrahepatic cholangiocarcinoma

Table 3 Univariate and multivariate analysis of risk factors for early recurrence

Variable	Univariate analysis, HR (95%CI)	P value	Multivariate analysis, HR (95%CI)	P value
Age > 65 years	0.89 (0.65-1.22)	0.467
Male sex	1.04 (0.76-1.42)	0.812
Hepatitis B/C	1.23 (0.88-1.72)	0.227
Cirrhosis	1.31 (0.89-1.93)	0.172
Tumor size > 5 cm	2.87 (2.06-3.99)	< 0.001	2.14 (1.52-3.01)	< 0.001
Multiple tumors	2.65 (1.91-3.68)	< 0.001	1.89 (1.34-2.67)	< 0.001
Bilobar distribution	2.34 (1.61-3.40)	< 0.001		NS
Poor differentiation	2.18 (1.57-3.03)	< 0.001		NS
Lymph node metastasis	3.42 (2.48-4.72)	< 0.001	2.43 (1.71-3.45)	< 0.001
Microvascular invasion	2.89 (2.09-4.00)	< 0.001	1.76 (1.25-2.48)	0.001
Perineural invasion	2.13 (1.55-2.93)	< 0.001		NS
R1 resection	3.21 (2.29-4.50)	< 0.001	2.01 (1.38-2.93)	< 0.001
CA19-9 > 200 U/mL	2.76 (2.00-3.81)	< 0.001	1.92 (1.37-2.69)	< 0.001
CEA > 5 ng/mL	1.89 (1.37-2.61)	< 0.001		NS
NLR > 3.0	2.03 (1.48-2.79)	< 0.001		NS
PLR > 150	1.78 (1.29-2.45)	< 0.001		NS
Major hepatectomy	1.42 (1.02-1.97)	0.038		NS
Blood loss > 500 mL	1.51 (1.10-2.07)	0.011		NS
Major complications	1.34 (0.91-1.97)	0.139
No adjuvant chemotherapy	1.67 (1.21-2.31)	0.002		NS

HR: Hazard ratio; CI: Confidence interval; CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; NS: Not significant in multivariate analysis.