Clinical features of post-colonoscopy colorectal cancer and real-world multi-scale correlation analysis

Table 3 Multinomial regression analysis, post-colonoscopy colorectal cancer vs confirmed diagnosis and non-post-colonoscopy colorectal cancer

Outcome	Characteristic	n	Event n	OR	95%CI	P value
Non-PCCRC	Sex
	Female	2059	7	Reference	Reference	-
	Male	3352	20	1.47	0.49-4.47	0.493
	Age
	< 60	2552	18	Reference	Reference	-
	≥ 60	2859	9	0.22	0.08-0.64	0.006
	Location
	Sigmoid colon	1284	6	Reference	Reference	-
	Ileocecal region	135	1	0.41	0.04-4.67	0.471
	Ascending colon	318	1	0.61	0.05-7.40	0.696
	Hepatic flexure	126	1	2.97 × 109	1.01 × 109, 8.71 × 109	< 0.001
	Transverse colon	127	4	8.50	0.75, 96.48	0.084
	Splenic flexure	21	0	0.01	0.01-0.01	< 0.001
	Descending colon	204	3	1.62	0.26-9.92	0.603
	Rectum	3125	10	2.45	0.61-9.84	0.207
	Anastomotic site	71	1	0.31	0.03-3.25	0.327
	Sedation
	Absent	2345	9	Reference	Reference	-
	Present	3066	18	0.48	0.14-1.59	0.229
	Bowl preparation
	Good	2147	14	Reference	Reference	-
	Excellent	591	0	0.00	-	-
	Inadequate	947	11	1.06	0.33-3.41	0.917
	Poor	1028	2	0.21	0.04-1.17	0.075
	Unclear	698	0	0.00	0.00-0.00	< 0.001
Confirmed diagnosis	Sex
	Female	2059	2039	Reference	Reference	-
	Male	3352	3306	0.83	0.42-1.65	0.598
	Age
	< 60	2552	2523	Reference	Reference	-
	≥ 60	2859	2822	0.50	0.24-1.02	0.056
	Location
	Sigmoid colon	1284	1266	Reference	Reference	-
	Ileocecal region	135	130	0.31	0.10-1.01	0.052
	Ascending colon	318	314	1.10	0.30-4.04	0.880
	Hepatic flexure	126	125	1.95 × 109	6.64 × 108, 5.73 × 109	< 0.001
	Transverse colon	127	122	1.34	0.17-10.48	0.782
	Splenic flexure	21	21	1.19 × 109	1.19 × 105, 1.19 × 105	< 0.001
	Descending colon	204	197	0.50	0.16-1.57	0.232
	Rectum	3125	3108	3.64	1.42-9.36	0.007
	Anastomotic site	71	62	0.07	0.03-0.18	< 0.001
	Sedation
	Absent	2345	2326	Reference	Reference	-
	Present	3066	3019	0.64	0.29-1.41	0.269
	Bowl preparation
	Good	2147	2118	Reference	Reference	-
	Excellent	591	590	2.12	0.26-17.42	0.483
	Inadequate	947	927	0.63	0.27-1.47	0.286
	Poor	1028	1015	0.74	0.32-1.70	0.485
	Unclear	698	695	1.78	0.50-6.40	0.374

CI: Confidence interval; OR: Odds ratio; PCCRC: Post-colonoscopy colorectal cancer.