Risk factors for enteral nutrition intolerance and its impact on prognosis in patients with severe acute pancreatitis

Table 3 Comparison of laboratory parameters between two groups, mean ± SD

Indicators	Intolerance group (n = 76)	Tolerance group (n = 119)	Test statistic	P value
Inflammatory markers
WBC count (× 109/L)	16.8 ± 6.2	14.2 ± 5.4	3.074	0.002
Neutrophil (%)	82.4 ± 8.6	78.9 ± 9.2	2.664	0.008
CRP (mg/L)1	186.4 (98.2, 274.6)	142.6 (76.8, 208.4)	-4.247	< 0.001
PCT (μg/L)1	3.8 (1.6, 8.2)	2.1 (0.8, 4.9)	-3.247	0.001
Pancreatic enzymes
Serum amylase (U/L)1	428 (186, 862)	384 (168, 726)	-1.428	0.153
Lipase (U/L)1	1246 (542, 2184)	1087 (468, 1896)	-1.723	0.085
Nutritional markers
Serum albumin (g/L)	26.8 ± 4.2	29.1 ± 4.8	-3.384	0.001
Prealbumin (μg/mL)	148.6 ± 32.4	168.2 ± 38.7	-3.689	< 0.001
Hemoglobin (g/L)	108.4 ± 18.6	112.8 ± 20.2	-1.534	0.126
Organ function markers
ALT (U/L)1	89.6 (42.8, 156.4)	68.2 (35.4, 128.6)	-2.146	0.032
AST (U/L)1	106.8 (58.2, 178.4)	84.6 (46.8, 142.2)	-2.218	0.026
Total bilirubin (μmol/L)1	48.6 (22.4, 86.8)	36.4 (18.2, 64.2)	-2.364	0.018
Serum creatinine (μmol/L)1	142.8 (86.4, 208.6)	108.2 (68.4, 156.8)	-2.968	0.003
BUN (mmol/L)1	12.4 (7.8, 18.6)	9.2 (5.6, 14.8)	-2.642	0.008
PT (second)	16.8 ± 4.2	14.6 ± 3.8	3.724	0.001
APTT (second)	42.6 ± 8.4	38.2 ± 7.6	3.698	0.001
INR1	1.52 (1.18, 1.96)	1.24 (1.06, 1.58)	-3.842	< 0.001
Metabolic markers
Blood glucose (mmol/L)	12.8 ± 4.6	10.4 ± 3.8	3.847	0.001
Serum sodium (mmol/L)	138.4 ± 6.8	140.2 ± 5.4	-1.984	0.048
Serum potassium (mmol/L)	3.8 ± 0.8	3.9 ± 0.7	-0.924	0.357
Serum chloride (mmol/L)	102.4 ± 8.2	104.1 ± 7.6	-1.468	0.144
Lactate (mmol/L)	2.8 ± 1.4	2.2 ± 1.1	3.242	0.001

¹Non-normally distributed data, expressed as median (interquartile range).

WBC: White blood cell; CRP: C-reactive protein; PCT: Procalcitonin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen; PT: Prothrombin time; APTT: Activated partial thromboplastin time; INR: International normalized ratio.